Julie M Cook

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RATIONALE Predicting corticosteroid response in COPD is important but difficult. Response is more likely to occur in association with eosinophilic airway inflammation, for which the fraction of exhaled nitric oxide (Fe(NO)) is a good surrogate marker. OBJECTIVES We aimed to establish whether Fe(NO) levels would predict the clinical response to oral(More)
Selected ion flow tube-mass spectrometry (SIFT-MS) can measure volatile compounds in breath on-line in real time and has the potential to provide accurate breath tests for a number of inflammatory, infectious and metabolic diseases, including diabetes. Breath concentrations of acetone in type 2 diabetic subjects undertaking a long-term dietary modification(More)
kilogram of body weight was given. A series of examinations of stool and sputum samples conducted over a 10-month period revealed no recurrence, and this was confirmed by the negative results of 2 stool cultures. The patient died in September 1998 of progressive HIV disease. This is the first report from Uganda of Strongyloides hyperinfection syndrome(More)
BACKGROUND Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health effects of ambient particulate air pollution from wood burning on school-age students in Christchurch, New Zealand, and to explore the utility of urine and exhaled breath condensate biomarkers of exposure in(More)
OBJECTIVE AND BACKGROUND The role of COPD self-management plans in improving health outcomes remains unclear. The objective of this study was to assess whether self-management plans administered in primary care have beneficial effects on quality of life, self-care behaviour and health outcomes in the long term for patients with COPD. MATERIAL, PATIENTS(More)
The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid samples using SIFT-MS. Until recently the(More)
BACKGROUND Alcohol-related harm is a major global health issue, and controls on alcohol marketing are one intervention utilized by governments. This study investigated the use of Google Street View (GSV) as a novel research method for collecting alcohol-related data in the urban environment. METHODS The efficacy of GSV and on-street observation by(More)
Selected ion flow tube mass spectrometry (SIFT-MS) is a sensitive technique capable of measuring volatile compounds (VCs) in complex gas mixtures in real time; it is now being applied to breath analysis. We investigated the effect of inhalers containing chlorofluorocarbons (CFCs) on the detection and measurement of haloamines in human breath. SIFT-MS mass(More)
In a time when mental health service providers are cutting costs and services, stakeholders need adequate information in the form of outcome measures to evaluate services based on quality. Outcome measures are particularly important for high-risk populations, where severe and persistent mental illness results in serious functional impairment of daily life.(More)
6-MeOTHBC binds to both high and low affinity receptors in human platelets. The beta-carboline is less active than chlorimipramine at the low affinity site, and it is weaker than methysergide, a known 5-HT antagonist, at the high affinity site. The other beta-carboline, B-CCE, is not active at either receptor in platelets. The data supports the view that(More)
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