Julie M Bullock

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STUDY OBJECTIVE To determine the effect of St. John's wort on the pharmacokinetics of imatinib mesylate. DESIGN Open-label, complete crossover, fixed-sequence, pharmacokinetic study. SETTING Clinical research center. SUBJECTS Ten healthy adult volunteers. INTERVENTION Single 400-mg oral doses of imatinib were administered before and after 2 weeks of(More)
Salmonella enterica serotype Typhi and nontyphoidal Salmonella remain major causes of morbidity and mortality worldwide. Ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol no longer provide reliable coverage of Salmonella, and fluoroquinoloes have emerged as first-line treatment options. Due to mounting evidence of decreased in vitro(More)
Therapeutic drug monitoring is used to minimize toxicity and maximize the therapeutic efficacy of busulfan, which shows high intra- and interpatient pharmacokinetic variability and erratic oral absorption. This study was designed to develop a pharmacokinetic model that could accommodate the erratic oral absorption of busulfan and to use this model to(More)
Arthroscopes and some instruments for arthroscopic surgery were prepared for use by soaking them for fifteen minutes in a cold solution of 2 per cent glutaraldehyde. This method was practical, economical, safe, and effective. Over a eight-year period we performed 12,505 arthroscopic procedures with an infection rate of 0.04 per cent. Although technically(More)
STUDY OBJECTIVE To evaluate the potential effect of tenofovir disoproxil fumarate (DF) on the pharmacokinetics of methadone. DESIGN Phase I, open-label, fixed-sequence, pharmacokinetic drug-drug interaction study. SETTING Clinical research center. SUBJECTS Fourteen volunteers receiving stable methadone maintenance therapy who were not infected with(More)
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