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In this paper we address the problem of nding the simulated system with the best (maximum or minimum) expected performance when the number of alternatives is nite, but large enough that ranking-and-selection procedures may require too much computation to be practical. Our approach is to use the data provided by the rst stage of sampling in a(More)
The Internet is changing the automotive industry as the traditional manufacturer and dealer structure faces increased threats from third party e-tailers. Dynamic pricing together with the Direct-to-Customer business model can be used by manufacturers to respond to these challenges. Indeed, by coordinating production and inventory decisions with dynamic(More)
Recent incidents of avian flu (H5N1) in Asia and the pandemic influenza cases in history (1918, 1957 and 1968) suggest that a future pandemic influenza is inevitable and likely imminent. Governments and non-governmental organizations prepare response plans on how to react to a pandemic influenza. In this paper, we study the logistics side of the problem,(More)
Although older adults are keeping their teeth longer, no national data are available on new caries in this age group. To characterize the extent of caries among older adults, we systematically reviewed studies on root caries incidence, increment, attack rate, and annual total (root + coronal) caries increment. We used a random-effects model to estimate(More)
To characterize the extent and severity of coronal caries among older US adults and document their need for prevention interventions, we systematically reviewed studies on coronal caries incidence, increment, and attack rate. We abstracted six studies and calculated summary measures using a random-effects model (95% confidence interval [95%CI]). We tested(More)
As the 2009 H1N1 influenza pandemic (H1N1) has shown, public health decision-makers may have to predict the subsequent course and severity of a pandemic. We developed an agent-based simulation model and used data from the state of Georgia to explore the influence of viral mutation and seasonal effects on the course of an influenza pandemic. We showed that(More)
We study jointly determining prices and production in a multiple period horizon under a general , non-stationary stochastic demand function with a discrete menu of prices. We assume that the available production capacity is limited and unmet demand is lost. We incorporate discretionary sales, when inventory may be set aside to satisfy future demand even if(More)
To my parents, Ana and Cornel, for their unconditional and unbreakable support iii ACKNOWLEDGEMENTS I would like to thank my family, especially my husband, who has never stopped believing in me, and has never complained being a mother and a father to our two children while I was working on my research. Without him I would have never become the person I am(More)
Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision(More)