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In this paper we address the problem of nding the simulated system with the best (maximum or minimum) expected performance when the number of alternatives is nite, but large enough that ranking-and-selection procedures may require too much computation to be practical. Our approach is to use the data provided by the rst stage of sampling in a(More)
Recent incidents of avian flu (H5N1) in Asia and the pandemic influenza cases in history (1918, 1957 and 1968) suggest that a future pandemic influenza is inevitable and likely imminent. Governments and non-governmental organizations prepare response plans on how to react to a pandemic influenza. In this paper, we study the logistics side of the problem,(More)
The Internet is changing the automotive industry as the traditional manufacturer and dealer structure faces increased threats from third party e-tailers. Dynamic pricing together with the Direct-to-Customer business model can be used by manufacturers to respond to these challenges. Indeed, by coordinating production and inventory decisions with dynamic(More)
We study jointly determining prices and production in a multiple period horizon under a general , non-stationary stochastic demand function with a discrete menu of prices. We assume that the available production capacity is limited and unmet demand is lost. We incorporate discretionary sales, when inventory may be set aside to satisfy future demand even if(More)
  • Andreea Popescu, Ellis L Johnson, Julie L Swann, Dirk P Günther, Hayriye Ayhan
  • 2006
To my parents, Ana and Cornel, for their unconditional and unbreakable support iii ACKNOWLEDGEMENTS I would like to thank my family, especially my husband, who has never stopped believing in me, and has never complained being a mother and a father to our two children while I was working on my research. Without him I would have never become the person I am(More)
BACKGROUND Rapid scale up of HIV treatment programs in sub-Saharan Africa has refueled the long-standing health policy debate regarding the merits and drawbacks of vertical and integrated system. Recent pilots of integrating outpatient and HIV services have shown an improvement in some patient outcomes but deterioration in waiting times, which can lead to(More)