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BACKGROUND Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited. METHODS In this 3-year open-label, multicenter trial, we evaluated 708 patients who had suboptimal glycated hemoglobin levels while taking metformin and sulfonylurea therapy. Patients were randomly assigned to(More)
BACKGROUND Trial research has predominantly focused on patient and staff understandings of trial concepts and/or motivations for taking part, rather than why treatment recommendations may or may not be followed during trial delivery. This study sought to understand why there was limited attainment of the glycaemic target (HbA(1c) ≤6.5%) among patients who(More)
INTRODUCTION Patients in intensive care units (ICUs) suffer from sleep deprivation arising from nursing interventions and ambient noise. This may exacerbate confusion and ICU-related delirium. The World Health Organization (WHO) suggests that average hospital sound levels should not exceed 35 dB with a maximum of 40 dB overnight. We monitored five ICUs to(More)
OBJECTIVE To identify the most appropriate format for results dissemination to maximise understanding of trial results. DESIGN Qualitative. SETTING Of the original 58 4-T trial centres, 34 agreed to take part in this ancillary research. PARTICIPANTS All participants from these centres were eligible. All 343 participants were sent questionnaires. (More)
BACKGROUND The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year costs, survival and quality of life following ICU admission in patients who required mechanical ventilation for acute respiratory distress(More)
INTRODUCTION Patients who develop intensive care unit (ICU) acquired delirium stay longer in the ICU, and hospital, and are at risk of long-term mental and physical health problems. Despite guidelines for patient assessment, risk limitation, and treatment in the ICU population, delirium and associated delusions remain a relatively common occurrence on the(More)
There is an omission in the first sentence of the Acknowledgments section. The correct sentence is: We are grateful to the Health Experiences Research Group, Department of Primary Care Health Sciences, University of Oxford for permission to conduct a secondary analysis of interviews collected by Dr. Suman Prinhja for their study of experiences of intensive(More)
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