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Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated(More)
Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be exported out of the cell, has triggered(More)
Few historical dates were more influential on the course of world history than October 12, 1492. It is on this morning that the Italian explorer Cristoforo Colombo spotted land after a five-week voyage across the Atlantic Ocean. The finding of unchartered shores was as much the fruit of Colombo’s earlier lobbying with private Italian investors and at the(More)
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