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BACKGROUND High angular resolution diffusion tensor imaging (HARD) is an MRI technique that exploits the mobility of water molecules to yield maps of structural order and directionality of white matter tracts with greater precision than six-direction diffusion tensor imaging (DTI) schemes. OBJECTIVE To assess whether HARD is more sensitive than(More)
OBJECTIVE To explore how men and women with cancer talk about using the internet. DESIGN Qualitative study using semistructured interviews collected by maximum variation sampling. SETTING Respondents recruited throughout the United Kingdom during 2001-2. PARTICIPANTS 175 men and women aged 19-83 years, with one of five cancers (prostate, testicular,(More)
OBJECTIVES The Biomedical Research Integrated Domain Group (BRIDG) project is a collaborative initiative between the National Cancer Institute (NCI), the Clinical Data Interchange Standards Consortium (CDISC), the Regulated Clinical Research Information Management Technical Committee (RCRIM TC) of Health Level 7 (HL7), and the Food and Drug Administration(More)
OBJECTIVE Examining the unresolved relationship between the lower motor neuron disorder progressive muscular atrophy (PMA) and ALS is important in clinical practice because of emerging therapies. METHODS Spinal and brainstem tissues donated from patients with ALS/motor neuron disorder (n = 81) were examined. Using retrospective case note review, the(More)
BACKGROUND A survey of students in three UK higher education establishments was undertaken to obtain information about students' physical and emotional well-being, their attitudes to, and beliefs about health, and the prevalence of risk factors for future ill health. METHODS Health was measured by the prevalence of longstanding illness and by the SF-36(More)
STUDY OBJECTIVE To examine the association between damp housing and adult health, taking into account a wide range of other factors that may influence health and could confound this relation. PARTICIPANTS AND SETTING A general population sample of adults, aged 18-64, from Oxfordshire, Buckinghamshire, Berkshire and Northamptonshire. DESIGN Secondary(More)
ness or other signs of severe malaria. On day 2 the parasitaemia was 4%. Treatment was changed to mefloquine, which was successful. His 4 year old brother, case 2, was febrile with 0.5% infected erythrocytes. His symptoms resolved with atovaquone and proguanil hydrochloride, and the parasites were cleared after three days. On day 28 he was again febrile(More)
OBJECTIVES To report on rejected choices of specialty as long-term careers and reasons for rejection. DESIGN Postal questionnaire survey. SETTING United Kingdom. PARTICIPANTS All graduates of 1996 and 1999 from UK medical schools during their first year after qualification. MAIN OUTCOME MEASURES Any career choice which had been seriously considered(More)
OBJECTIVES To explore the attitudes of women with screen-detected ductal carcinoma in situ (DCIS) towards information provision for mammographic screening. SETTING Respondents recruited throughout the UK during 2003-2004. METHODS Qualitative study using semi-structured interviews. PARTICIPANTS Ten women diagnosed with DCIS as a result of mammographic(More)