Julie Bourbeillon

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Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a(More)
volume 28 number 7 july 2010 nature biotechnology With the broadening availability of tools and methods, researchers have to define the most efficient binder applicable to the method and approach they have selected. These applications are carried out under different experimental conditions, which affect the choice of affinity reagent used. For example,(More)
Image analysis is increasingly used in plant phenotyping. Among the various imaging techniques that can be used in plant phenotyping, chlorophyll fluorescence imaging allows imaging of the impact of biotic or abiotic stresses on leaves. Numerous chlorophyll fluorescence parameters may be measured or calculated, but only a few can produce a contrast in a(More)
In oncology research, Tissue Microarray (TMA) technology allows for the mass treatment of hundreds of tissue samples and rapid visualisation of molecular targets. Since this technique is relatively new, there are very few dedicated information systems and little formalised knowledge about the technique is available. We therefore intend to set up an(More)
Beyond classical techniques to explore a document collection such as Information Retrieval and graphical visualisation we present in this paper an analytic view which combines the expression of a goal-centered query and the construction of a virtual multimedia document. Building this synthetic document is considered as a complex adaptation problem. We(More)
New technologies and equipment allow for mass treatment of samples and research teams share acquired data on an always larger scale. In this context scientists are facing a major data exploitation problem. More precisely, using these data sets through data mining tools or introducing them in a classical experimental approach require a preliminary(More)
La technique des « Tissue MicroArrays » (TMA) est une technologie récente, déjà très utilisée en oncologie (Kallioniemi et al., 2001). Selon cette technique: 1) on sélectionne des patients, en fonction de l'étude à réaliser ; 2) un pathologiste analyse une lame histologique des biopsies des patients et détermine des régions d'intérêt, puis 3) on réalise le(More)
RÉSUMÉ. Le volume de documents disponible sur l'Internet rend difficile les tâches de recherche d'informations. Parallèlement, des efforts vers la personnalisation de l'Internet permettent l'adaptation des pages web à l'utilisateur. Pour ce faire, les travaux s'orientent vers les concepts des systèmes d'informations adaptatifs et de la génération de résumés(More)
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