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AIMS Poor butanol tolerance of solventogenic stains directly limits their butanol production during industrial-scale fermentation process. This study was performed to search for micro-organisms possessing elevated tolerance to butanol. METHODS AND RESULTS Two strains, which displayed higher butanol tolerance compared to commonly used solventogenic(More)
OBJECTIVE To investigate whether partial unilateral ureteric obstruction (PUUO) produces renal dysplasia in newborn rats. MATERIALS AND METHODS Left mild (in 31) or severe (in 34) PUUO was induced in 2-day-old rats by embedding a quarter or two-thirds of the ureter into the psoas muscles, respectively. Sham-operated control rats (36) were assessed in(More)
The epicardial coronary arteries experience significant torsion in the axial direction due to changes in the shape of the heart during the cardiac cycle. The objective of this study was to determine the torsional mechanical properties of the coronary arteries under various circumferential and longitudinal loadings. The coronary artery was treated as a(More)
Non-enzymatic glycosylation of vascular wall collagen is considered to be most important in the pathogenesis of diabetic microangiopathy, and glycosylated collagens are reported to bind immunoglobulins in vivo. We investigated the occurrence of IgG or IgM deposits in the microvasculature of certain organs of diabetics using routine autopsy materials.(More)
The goal of this study is to quantitatively describe the remodeling of the zero-stress state of the femoral artery in flow overload. Increased blood flow, approximately as a unit step change, was imposed on the femoral artery by making an arteriovenous (a-v) fistula with the epigastric vein. The a-v fistula was created in the right leg of 36 rats, which(More)
A focal and transitory inflammation induced by injection of complete Freund's adjuvant (CFA) in the submandibular skin of mice elicits pain behavior that persists for several weeks after the initial inflammation has resolved. Chronic pain, assessed as tactile hypersensitivity to stimulation with von Frey filaments, was evident from 1-7 weeks following CFA(More)
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as a novel MLKL-interacting protein. We(More)
We have studied nearly 100 patients with beta-thalassaemia major and 60 patients with Hb H disease who were attending the Haematology Clinic of Guangxi Medical College. Treatment of the patients was limited and only a few patients with beta-thalassaemia major received blood transfusion(s). As a result, the severe anaemia has led to early death at 3-4 years(More)