Julie Ann Jordan

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PURPOSE To identify the causative mutation in a canine cone-rod dystrophy (crd3) that segregates as an adult onset disorder in the Glen of Imaal Terrier breed of dog. METHODS Glen of Imaal Terriers were ascertained for crd3 phenotype by clinical ophthalmoscopic examination, and in selected cases by electroretinography. Blood samples from affected cases(More)
PURPOSE To identify the causative mutations in two early-onset canine retinal degenerations, crd1 and crd2, segregating in the American Staffordshire terrier and the Pit Bull Terrier breeds, respectively. METHODS Retinal morphology of crd1- and crd2-affected dogs was evaluated by light microscopy. DNA was extracted from affected and related unaffected(More)
PURPOSE To clone, map, and determine the site of expression (mRNA and protein) of the alpha subunit of the receptor for ciliary neurotrophic factor (CNTFRalpha) in the normal adult canine retina. METHODS The complete coding sequence of the canine CNTFRalpha cDNA was cloned, and radiation hybrid (RH) mapping was used to determine the chromosomal(More)
Free-radical-induced oxidative damage has been implicated as an important mechanism responsible for the toxicity of both active and passive smoking. Cigarette smoke contains short- and long-lived radicals and can stimulate cellular production of highly reactive oxygen species. One of the antioxidant enzymes that is protective against reactive oxygen-induced(More)
PURPOSE To identify the causative mutation of canine progressive retinal atrophy (PRA) segregating as an adult onset autosomal recessive disorder in the Basenji breed of dog. METHODS Basenji dogs were ascertained for the PRA phenotype by clinical ophthalmoscopic examination. Blood samples from six affected cases and three nonaffected controls were(More)
METHODS. The complete coding sequence of the canine CNTFR cDNA was cloned, and radiation hybrid (RH) mapping was used to determine the chromosomal localization of the gene. CNTFR mRNA expression in retina and other tissues was examined by reverse transcription–polymerase chain reaction. The cellular distribution of CNTFR in the canine retina was studied by(More)
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