Julie A. Stortz

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Sepsis and trauma are both leading causes of death in the United States and represent major public health challenges. Murine models have largely been used in sepsis and trauma research to better understand the pathophysiological changes that occur after an insult and to develop potential life-saving therapeutic agents. Mice are favorable subjects for this(More)
INTRODUCTION The use of human recombinant activated protein C (rhAPC) for the treatment of severe sepsis remains controversial despite multiple reported trials. The efficacy of rhAPC remains a matter of dispute. We hypothesized that patients with septic shock who were treated with rhAPC had an improved in-hospital mortality compared to patients with septic(More)
Early host recognition of microbial invasion or damaged host tissues provides an effective warning system by which protective immune and inflammatory processes are initiated. Host tissues responsible for continuous sampling of their local environment employ cell surface and cytosolic pattern recognition receptors (PRRs) that provide redundant and(More)
Despite advances in critical care medicine, neonatal sepsis remains a major cause of morbidity and mortality worldwide, with the greatest risk affecting very low birth weight, preterm neonates. The presentation of neonatal sepsis varies markedly from its presentation in adults, and there is no clear consensus definition of neonatal sepsis. Previous work has(More)
This issue of the Journal of Leukocyte Biology headlines with some impressive findings from the El Gazzar laboratory [1]. In their work, “Myeloid cellspecific deletion of Cebpb decreases sepsisinduced immunosuppression in mice,” the authors investigated the role of C/EBPb in the generation, maturation, and differentiation of murine Gr1CD11b MDSCs in both(More)
INTRODUCTION Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic critical illness (CCI), persistent low-grade organ dysfunction(More)
BACKGROUND Many sepsis survivors develop chronic critical illness (CCI) and are assumed to be immunosuppressed, but there is limited clinical evidence to support this. We sought to determine whether the incidence of secondary infections and immunosuppressive biomarker profiles of patients with CCI differ from those with rapid recovery (RAP) after sepsis. (More)
OBJECTIVE To determine the incidence and risk factors of chronic critical illness after severe blunt trauma. DESIGN Prospective observational cohort study (NCT01810328). SETTING Two-level one trauma centers in the United States. PATIENTS One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who survived beyond 48 hours after(More)
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