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Mutations in the glucocerebrosidase gene (GBA) are associated with Gaucher's disease, the most common lysosomal storage disorder. Parkinsonism is an established feature of Gaucher's disease and an increased frequency of mutations in GBA has been reported in several different ethnic series with sporadic Parkinson's disease. In this study, we evaluated the(More)
Mutations in the glucocerebrosidase (GBA) gene have been implicated in increased formation of Lewy bodies (LBs) in Parkinson's disease (PD). We found GBA mutation status not to be significantly associated with the density of cortical LBs, after adjusting for sex, age at death, duration of PD and presence of dementia. Comparison of GBA carriers to PD(More)
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with(More)
The diffuse angiomatosis of the spleen is a rare splenic proliferation. Spontaneous rupture is the main, potentially lethal complication, found in 25 % of cases. The problem with these vascular tumors is preoperative diagnosis, because they are asymptomatic for a long time. First-choice therapy is limited resection. In the case of rupture, splenectomy is a(More)
Massive Blutungen aus dem oberen Gastrointestinaltrakt gehören zu den seltenen Komplikationen nach einer partiellen Duodenopankreatektomie. Quellen für diese Blutungen sind Ulzera im Magenrest oder Blutungen im Anastomosenbereich. Blutungen sind meist in den ersten 7 bis 10 Tagen postoperativ zu beobachten. Anhand einer Kasuistik, wird über eine(More)
The management of patients with acute stroke regarding treatment of thromboembolism is supported by a limited evidence base. We present the case of a 55-year-old female patient who initially presented with an ischaemic cerebral infarct with haemorrhagic transformation. Her clinical recovery was complicated by cardiac arrest secondary to massive pulmonary(More)
Medical processes can be modeled using different methods and notations. Currently used modeling systems like Business Process Model and Notation (BPMN) are not capable of describing the highly flexible and variable medical processes in sufficient detail. We combined two modeling systems, Business Process Management (BPM) and Adaptive Case Management (ACM),(More)