Juliane Engel

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Male rhesus monkeys (Macaca mulatta) of different age groups representing the species life span were fed ad libitum or a 30% reduced calorie diet over a 7-yr period. During the first 2-3 yr of this longitudinal study, glucose and insulin levels were not altered by diet restriction (DR). However, reductions in fasting blood glucose became apparent in DR(More)
QUESTIONS In limb salvage surgery for extremity soft-tissue sarcoma (sts), what is an adequate surgical margin?What is the appropriate number of samples to take from the margins of a surgical resection specimen?What is the appropriate handling of surgical resection specimens? BACKGROUND Surgery is the primary treatment for extremity sts. The combination(More)
A single electroshock stimulation (EST) by means of a conventional clinical EST apparatus was administered to 40 rats. Ten minutes after the start of general convulsions the animals were sacrificed. Corpus striatum was analyzed for dopamine (DA) and homovanillic acid (HVA). A statistically not significant increase of DA and a highly significant increase of(More)
IGF-I is a neuroprotective hormone, and neurodegenerative disorders, including Alzheimer's disease, have been associated with decreased serum IGF-I concentration. In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations. In young(More)
Still's murmur is the most common innocent heart murmur in children and considered flow related; however, so far the cause of the murmur has not yet been fully explained. Assessment of the hemodynamic ventriculo-arterial interaction and the proportional anatomical dimensions of the left ventricle and the aortic root were the objective for this study. This(More)
Amperozide, a new putatively antipsychotic compound, has been evaluated for its effect on conditioned avoidance response and food-reinforced lever-pressing. Given alone, amperozide was almost equipotent to clozapine, but less potent than haloperidol in both test models. It was found that there was a statistically significant synergism, in these two models,(More)
Repeated electroshock treatment (EST) on three consecutive days was administered to 72 rats. The last treatment was given immediately after an injection of a tryptophan-hydroxylase inhibitor, H 22/54. The animals were killed three hours later, two to four brain stems were pooled, analysed for 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid(More)
Objectives/Methods: To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990. Results: One intention-to-treat Class I randomized, controlled trial of surgery for mesial temporal lobe epilepsy found that 58% of(More)