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Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia.
- D. Rabello, A. Lucena-Araujo, +6 authors Fábio Pittella Silva
- Blood cells, molecules & diseases
EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to… Expand
GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death
- Juliana Carvalho Rocha Alves-Silva, J. L. de Carvalho, +6 authors F. Saldanha-Araujo
- Investigational New Drugs
- 31 May 2018
SummaryBackground Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.… Expand