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Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common known genetic cause of inherited and idiopathic Parkinson's disease (PD) in different populations. The predicted multifunctionality of LRRK2 product and the pleomorphic pathology associated with LRRK2 mutations place this gene as a potential candidate for other(More)
The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such large cohorts, we describe here a novel(More)
This paper presents a description and the evaluation of the Netuno supercomputer, a high-performance cluster installed at Federal University of Rio de Janeiro in Brazil. The results for the High Performance Linpack (HPL) benchmark and two real applications are reported. Since building a high-performance cluster for running a wide range of applications is a(More)
This paper presents the Netuno supercomputer, a large-scale cluster installed at Federal University of Rio de Janeiro in Brazil. A detailed performance evaluation of Netuno is presented, depicting its computational and I/O performance, as well as the results for two real-world applications. Since building a high- performance cluster for running a wide range(More)
To compare the effectiveness of abdominal wall closure using the vacuum-assisted closure (NPC) as described by Barker et al. with an institutional protocol using a double polyvinyl bag in the first surgery, which is changed in subsequent surgeries to a polyvinyl bag placed over the bowel loops and a prolene mesh attached to the abdominal fascia (MMFC).(More)
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