Julian Weichsel

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The lamellipodium of migrating animal cells protrudes by directed polymerization of a branched actin network. The underlying mechanisms of filament growth, branching, and capping can be studied in in vitro assays. However, conflicting results have been reported for the force-velocity relation of such actin networks, namely both convex and concave shapes as(More)
The actin cytoskeleton modulates a large variety of physiological and disease-related processes in the cell. For example, actin has been shown to be a crucial host factor for successful infection by HIV-1, but the underlying mechanistic details are still unknown. Automated approaches open up the perspective to clarify such an issue by processing many(More)
Migration of motile cells on flat substrates is usually driven by the polymerization of a flat actin filament network. Theoretical models have made different predictions regarding the distribution of the filament orientation in the lamellipodium with respect to the direction of motion. Here we show how one can automatically reconstruct the orientation(More)
Laser-induced particle accelerators have been recognized as a potential proton source for radiotherapeutic applications in recent years. However, there are still major difficulties--especially regarding the resulting proton spectra--to overcome for a successful application in the clinic. Here we elaborate on the physics of double-layer targets to propose a(More)
The directed polymerization of actin networks is an essential element of many biological processes, including cell migration. Different theoretical models considering the interplay between the underlying processes of polymerization, capping, and branching have resulted in conflicting predictions. One of the main reasons for this discrepancy is the(More)
Propulsion by growing actin networks is a universal mechanism used in many different biological systems, ranging from the sheet-like lamellipodium of crawling animal cells to the actin comet tails induced by certain bacteria and viruses in order to move within their host cells. Although the core molecular machinery for actin network growth is well preserved(More)
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