Julian Mattes

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The availability of cellular markers tagged with the green fluorescent protein (GFP) has recently allowed a large number of cell biological studies to be carried out in live cells, thereby addressing the dynamic organization of cellular structures. Typically, microscopes capable of video recording are used to generate time-resolved data sets. Dynamic(More)
Understanding complex cellular processes requires investigating the underlying mechanisms within a spatiotemporal context. Although cellular processes are dynamic in nature, most studies in molecular cell biology are based on fixed specimens, for example, using immunocytochemistry or fluorescence in situ hybridization (FISH). However, breakthroughs in(More)
We provide the results from a spectral analysis of nuclear decay data displaying annually varying periodic fluctuations. The analyzed data were obtained from three distinct data sets: Si and Cl decays reported by an experiment performed at the Brookhaven National Laboratory (BNL), Mn decay reported by the Children’s Nutrition Research Center (CNRC), but(More)
In this paper we present a new approach for automated cell detection in single frames of 2D microscopic phase contrast images of cancer cells which is based on learning cellular texture features. The main challenge addressed in this paper is to deal with clusters of cells where each cell has a rather complex appearance composed of sub-regions with different(More)
Computational modeling and imaging in biology and medicine are gaining more and more interest with the discovery of in-depth structural and functional knowledge at all space and time scales (molecule to proteins, cells to organs and organizms). The recursion between description levels for highly dynamical, interacting and complex systems, i.e the(More)