Julian Hargreaves

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OBJECTIVES To model the determinants of serious operative and post-operative complications of hysterectomy and their potential risk factors. DESIGN A prospective cohort of women undergoing hysterectomies for benign indications in 1994/1995, with a six-week postsurgery follow up. POPULATION AND SETTING A total of 37,512 women from 276 NHS and 145 private(More)
OBJECTIVES To describe hysterectomies practised in 1994 and 1995: the patients, their surgery and short term outcomes. DESIGN One of two large cohorts, with prospective follow up, recruited to compare the outcomes of endometrial destruction with those of hysterectomy. SETTING England, Wales and Northern Ireland. POPULATION All women who had(More)
Ninety day-case or short stay patients were allocated to three groups in a double-blind study. The groups received oral midazolam 15 mg, oral temazepam 20 mg or placebo approximately 1 h before surgery. Midazolam was superior to temazepam regarding anxiolysis, sedation and amnesia, but temazepam was superior to placebo. However, delay in immediate and late(More)
Propofol in a 1% emulsion was used to induce anaesthesia in 20 female patients premedicated with diazepam (10 mg). A dose of 2.5 mg kg-1 produced a rapid loss of consciousness and only minor excitatory effects. Discomfort during the injection was not severe. Cardiovascular changes included a fall in blood pressure similar to that which occurs with other(More)
OBJECTIVES To study the frequency of complications of endometrial resection and ablation for menstrual disturbances and the influence of the experience of the operators. DESIGN Prospective survey with additional retrospective reporting by theatre staff. SETTING 300 National Health Service and independent hospitals in the United Kingdom (excluding(More)
Sixty out-patients undergoing cystoscopy were allocated randomly into two groups. No premedication was given. Induction of anaesthesia was preceded by intravenous alfentanil 7 micrograms kg-1 given over 20 s, followed by methohexitone 1.5-2 mg kg-1 or propofol 2 mg kg-1, given over 20 s. Anaesthesia was maintained by increments of alfentanil, methohexitone(More)
The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and(More)
Description: 1. Primary purpose: This program is a comprehensive set of approaches, including assessment, individual, group, and family, that can be tailored to the specific needs of individual programs. 2. Target population: Adults with severe mental illness, most commonly those with psychotic disorders, but may include anxiety disorders such as(More)