Julia Zaccai

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Substantial variation in the prevalence of dementia in Parkinson's disease (PDD) has been reported. The aim of this study was to review systematically and critically previous studies of the prevalence of PDD using PubMed to search the literature. Studies focusing on PD and PDD, as well as those examining on the epidemiology of dementia subtypes, were(More)
BACKGROUND Substantial variation in the prevalence of Dementia with Lewy Bodies (DLB) has been reported with estimates ranging from 0 to 26.3% of all dementia cases, potentially making it the second most common dementia subtype. OBJECTIVES The aim of this study was to review systematically and critically for the first time previous studies of the clinical(More)
BACKGROUND Behavioural and psychological symptoms of dementia (BPSD) are major contributors to the burden of dementia. AIMS To describe the prevalence, correlates and course of BPSD in the population of England and Wales. METHOD The prevalence of 12 symptoms was estimated in 587 participants with dementia and 2050 participants without dementia as part(More)
Assessing the quality of an epidemiological study equates to assessing whether the inferences drawn from it are warranted when account is taken of the methods, the representativeness of the study sample, and the nature of the population from which it is drawn. Bias, confounding, and chance can threaten the quality of an epidemiological study at all its(More)
BACKGROUND Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised. METHODS A systematic review of the methods of population-based neuropathological studies of dementia was carried out. These studies were assessed in relation to their representativeness of underlying populations and the(More)
Studies with strong selection biases propose that alpha-synucleinopathy (AS) spreads upwards and downwards in the neuraxis from the medulla, that amygdala-dominant AS is strongly associated with Alzheimer’s disease (AD), and that a more severe involvement of the cerebral cortex is correlated with increasing risk of dementia. This study examines the(More)
OBJECTIVE Dementia with Lewy bodies is an α-synucleinopathy characterized by neocortical Lewy-related pathology (LRP). We carried out a genome-wide association study (GWAS) on neocortical LRP in a population-based sample of subjects aged 85 or over. METHODS LRP was analyzed in 304 subjects in the Vantaa 85+ sample from Southern Finland. The GWAS included(More)
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