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Enhanced perceptual processing of emotional stimuli may be accomplished via amygdala-back-projections into the inferior temporal cortex. In the current study, we investigated the influence of stimulus novelty on the covariation between these brain regions during emotional picture processing. Participants viewed repeatedly presented and novel emotional and(More)
Brain regions associated with the processing of emotional stimuli are often also associated with the processing of social stimuli. Therefore, this network consisting of the amygdala, the anterior insula, the superior temporal sulcus (STS), and the orbitofrontal cortex (OFC) may rather be involved in more general relevance detection which should be(More)
There is abundant evidence in memory research that emotional stimuli are better remembered than neutral stimuli. However, effects of an emotionally charged context on memory for associated neutral elements is also important, particularly in trauma and stress-related disorders, where strong memories are often activated by neutral cues due to their emotional(More)
This study explored defensive response mobilization as well as fMRI responses during sustained exposure to phobia-relevant stimuli. To test the specificity of affective physiology and brain activation, neutral and other affective stimuli were included. Phobia-specific startle potentiation was maintained and autonomic responses even increased during(More)
Keeping aware of the locations of objects while one is moving requires the updating of spatial representations. As long as the objects are visible, attentional tracking is sufficient, but knowing where objects out of view went in relation to one's own body involves an updating of spatial working memory. Here, multiple object tracking was employed to study(More)
Startle blink as well as skin conductance responses (SCR) are widely used indices of learning processes associated with fear conditioning and extinction. During safety learning, the amygdala is under top-down inhibitory control by the prefrontal cortex (PFC). The capacity of the PFC to exert inhibitory control over subcortical brain structures may be(More)
Multiple sclerosis (MS) is associated with the occurrence of white matter plaques in the central nervous system. These are frequently located in areas interconnecting areas associated with the processing of emotions. Although recent behavioral studies indicated social and affective disturbances in many of these patients, functional studies investigating(More)
BACKGROUND Disturbances that occur in patients with multiple sclerosis (MS) are not restricted to motor, sensory, or urinary functions; they also include cognitive dysfunction, fatigue, and depression. Moreover, people with MS are known to have fewer social activities and a reduced quality of life. One aspect of social interaction is accurate recognition of(More)
The current study investigated the neural networks activated during the anticipation of potentially threatening body symptoms evoked by a guided hyperventilation task in a group of participants reporting either high or low fear of unexplained somatic sensations. 15 subjects reporting high and 14 subjects reporting low fear of somatic symptoms first learned(More)
Repetitive exposure to feared stimuli is considered as the essential element in therapy with phobic patients. However, the mechanisms mediating symptom reduction and their underlying neurobiological processes are poorly understood. Therefore, we presented the same fear-relevant and neutral stimuli repeatedly to individuals with high and low fear of animals(More)