Julia Tzu-Ya Weng

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The prevalence of type 2 diabetes is increasing at an alarming rate. Various complications are associated with type 2 diabetes, with diabetic nephropathy being the leading cause of renal failure among diabetics. Often, when patients are diagnosed with diabetic nephropathy, their renal functions have already been significantly damaged. Therefore, a risk(More)
In eukaryotes, ubiquitin-conjugation is an important mechanism underlying proteasome-mediated degradation of proteins, and as such, plays an essential role in the regulation of many cellular processes. In the ubiquitin-proteasome pathway, E3 ligases play important roles by recognizing a specific protein substrate and catalyzing the attachment of ubiquitin(More)
Alcoholism has always been a major public health concern in Taiwan, especially in the aboriginal communities. Emerging evidence supports the association between DNA methylation and alcoholism, though very few studies have examined the effect of chronic alcohol consumption on the epignome. Since 1986, we have been following up on the mental health conditions(More)
Protein S-sulfenylation is a type of post-translational modification (PTM) involving the covalent binding of a hydroxyl group to the thiol of a cysteine amino acid. Recent evidence has shown the importance of S-sulfenylation in various biological processes, including transcriptional regulation, apoptosis and cytokine signaling. Determining the specific(More)
In several real-life applications, sequence databases, in general, are updated incrementally with time. Some discovered sequential patterns may be invalidated and some new ones may be introduced by the evolution of the database. When a small set of sequences grow, or when some new sequences are added into the database, re-mining sequential patterns from(More)
Tuberculosis (TB) is the second most common cause of death from infectious diseases. About 90% of those infected are asymptomatic--the so-called latent TB infections (LTBI), with a 10% lifetime chance of progressing to active TB. To further understand the molecular pathogenesis of TB, several molecular studies have attempted to compare the expression(More)
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disorder characterized by the progressive obstruction of airflow and is currently the fourth leading cause of death in the world. The pathogenesis of COPD is thought to involve bacterial infections and inflammations. Owing to advancement in sequencing technology, evidence is emerging that(More)
Closed sequential patterns have attracted researchers’ attention due to their capability of using compact results to preserve the same expressive power as conventional sequential patterns. However, studies to date have mainly focused on mining conventional patterns from time interval-based data, where each datum persists for a period of time. Few research(More)
1Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 320, Taiwan 2Innovation Center for Big Data and Digital Convergence, Yuan Ze University, Taoyuan 320, Taiwan 3Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan 320, Taiwan 4Institute of Tropical Plant Sciences, National Cheng Kung University,(More)