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Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to (Coronavirus) CoV epidemics. Neither vaccines nor therapeutics are available against human and animal CoVs.(More)
A group of 57 women, who had been hospitalised for puerperal psychiatric disorders from 1958 to 1977, were reexamined in 1982. The aim of the study was to determine the proportion of patients who had suffered from nonpuerperal psychotic relapses or other subsequent psychopathology, to define the sample diagnostically, taking into account progress in(More)
The EPs to bilaterally presented non-verbal and non-cognitive visual and auditory stimuli were studied in 15 schizophrenics and 15 normal subjects. Many anomalies of exogenous components of VEPs and AEPs were observed in schizophrenics in comparison with control subjects, pointing to an abnormal cerebral functioning. So, the patients presented: (1) a less(More)
Ten healthy volunteers were injected i.v. with 5 mg Ro 15-1788, a specific benzodiazepine antagonist, or placebo in a double-blind randomised design. In the EEG, Ro 15-1788 led--with some topographical variations--to a diminution of theta and alpha power, an increase of alpha mean frequency and a decrease of delta mean frequency. In auditory evoked(More)
The therapeutic efficacy of lithium added to tricyclic antidepressants (TCA) or related thymoleptics was investigated in 27 endogenous depressive patients responding unsatisfactorily to these drugs alone. All patients received lithium during two weeks, however, with a delay of one week in 13 of them, the attribution to active treatment or placebo for the(More)
A group of 80 women suffering from a severe psychiatric post-partum disorder and hospitalized for the first time in their lives was followed up between 4 and 35 years later. Besides the further evolution of psychic health of the patients, the occurrence of endogenous (i.e., functional) psychoses in first degree relatives was investigated. A global morbidity(More)
A subgroup of 16 out of 30 endogenous depressive inpatients (cf. part I), treated for 3 weeks with 150 mg amitriptyline (AT) daily, participated in a pharmacogenetic study: all were phenotyped with debrisoquine and 3 of them with mephenytoin. Four patients were found to be poor metabolizers (PMs) of debrisoquine and one of mephenytoin. Plasma levels of AT +(More)
In the last few years several open studies supported the hypothesis that L-5-HTP may be an effective antidepressant. Because of the lack of a controlled double-blind trial we started our own investigations to confirm this hypothesis in L-5-HTP. In 1972 we performed two open dose finding trials with L-5-HTP in combination with Benzerazide. These open studies(More)
A group of 119 patients suffering from a severe psychiatric postpartum disorder who were admitted for the first time in their life to a psychiatric hospital has been investigated. The onset of illness occurred within 3 months following delivery. The patients represented 92% of the total sample fulfilling the inclusion criteria. A follow-up investigation was(More)
10 chronic schizophrenics were treated with baclofen for 30 days in addition to the neuroleptic maintenance medication. The psychopathological findings were documented in intervals of 5 days using a global rating and the BPRS scale. 3 patients showed a definite slight improvement of their clinical condition, 2 patients showed a questionable improvement,(More)