Julia Sabio García

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Autophagy is the catabolic degradation of cellular cytoplasmic constituents via the lysosomal pathway that physiologically elicits a primarily cytoprotective function, but can rapidly be upregulated in response to stressors thereby inducing cell death. We have reported that the balance between the BCL2 family proteins BOK and MCL1 regulates human(More)
Trophoblast cell fusion is a prerequisite for proper human placental development. Herein we examined the contribution of Par6 (Partitioning defective protein 6), a key regulator of cell polarity, to trophoblast cell fusion in human placental development. During early placentation, Par6 localized to nuclei of cytotrophoblast cells but with advancing(More)
Chromobacterium violaceum is a Gram-negative proteobacteria found in water and soil; it is widely distributed in tropical and subtropical regions, such as the Amazon rainforest. We examined protein expression changes that occur in C. violaceum at different growth temperatures using electrophoresis and mass spectrometry. The total number of spots detected(More)
Parkinson’s disease (PD) is a neurodegenerative disorder that results from the loss of dopaminergic neurons in the substantia nigra of the brain. α-Synuclein (α-Syn) is the disease-associated protein that is prevalent among PD patients. Aggregations of this protein result in the formation of Lewy bodies present in all PD cases. Familial mutations of α-Syn:(More)
The Mce proteins are encoded in a variable number of operons (from one to eight) in all Mycobacterium species. A role in the transport of host and mycobacterial lipids has been demonstrated for some Mce proteins in the pathogen Mycobacterium tuberculosis but little is known about these proteins in Mycobacterium smegmatis, a soil dweller species. To(More)
BACKGROUND This study explored the biological effects of metformin on prostate cancer (PCa) cells and determined molecular pathways and epigenetic regulators implicated in its mechanism of action. METHODS We performed mRNA expression profiling in 22Rv1 cells following 2.5 mM and 5 mM metformin treatment. Genes significantly modified by metformin treatment(More)
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