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  • Julia S. Kimbell, M N Godo, Elizabeth A. Gross, Dennis R Joyner, Richard B. Richardson, Kevin T. Morgan
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1997 (First Publication: 1 August 1997)
  • Data from laboratory animal experiments are often used in setting guidelines for safe levels of human exposure to inhaled materials. The F344 rat has been used extensively in laboratory experimentsExpand
  • Clay B Frederick, Michelle Bush, +7 authors James S. Ultman
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1998 (First Publication: 1 September 1998)
  • This study provides a scientific basis for interspecies extrapolation of nasal olfactory irritants from rodents to humans. By using a series of short-term in vivo studies, in vitro studies with nasalExpand
  • Rory B. Conolly, Julia S. Kimbell, +4 authors Frederick J. Miller
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 2004 (First Publication: 22 July 2004)
  • Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are of interest, sinceExpand
  • Rory B. Conolly, Patrick D. Lilly, Julia S. Kimbell
  • Biology, Medicine
  • Environmental health perspectives
  • 2000 (First Publication: 1 October 2000)
  • Formaldehyde inhalation causes formation of DNA-protein cross-links (DPX) in the nasal mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of the mechanism by whichExpand
  • Julia S. Kimbell, Rebecca A. Segal, +6 authors Frederick J. Miller
  • Medicine, Chemistry
  • Journal of aerosol medicine : the official…
  • 2007 (First Publication: 1 March 2007)
  • Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front of the nose. Here, nasal spray behavior was studiedExpand
  • Julia S. Kimbell, Elizabeth A. Gross, Dennis R Joyner, M N Godo, Kevin T. Morgan
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1993 (First Publication: 1 August 1993)
  • For certain inhaled air pollutants, such as reactive, water soluble gases, the distribution of nasal lesions observed in F344 rats may be closely related to regional gas uptake patterns in the nose.Expand