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Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain
TLDR
This work proposes ribosomal multilocus sequence typing (rMLST), an approach which indexes variation of the 53 genes encoding the bacterial ribosome protein subunits (rps genes), as a means of integrating microbial genealogy and typing, and employs curated reference sequences to identify gene variants efficiently and rapidly.
Description and Nomenclature of Neisseria meningitidis Capsule Locus
TLDR
A comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.
A genomic approach to bacterial taxonomy: an examination and proposed reclassification of species within the genus Neisseria
TLDR
Data showed that isolates classified as Neisseria polysaccharea are polyphyletic and probably include more than one taxonomically distinct organism, demonstrating that ribosomal multilocus sequence typing (rMLST) is a practicable and powerful means of characterizing bacteria at all levels, from domain to strain.
Nasal Inoculation of the Commensal Neisseria lactamica Inhibits Carriage of Neisseria meningitidis by Young Adults: A Controlled Human Infection Study.
TLDR
The inhibition of meningococcal carriage by N. lactamica is even more potent than after glycoconjugate mening bacteria vaccination, and could be a novel bacterial medicine to suppress meningitis outbreaks.
Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing
TLDR
The seven loci Neisseria MLST scheme was readily adapted to N. gonorrhoeae isolates, providing a highly discriminatory typing method, and permitted phylogenetic and population genetic inferences to be made, including direct comparisons with N. meningitidis and N. lactamica.
Genetic Diversity and Carriage Dynamics of Neisseria lactamica in Infants
TLDR
Carriage was generally long-lived, with an average rate of loss of under 1% per week during the 28 weeks following acquisition, and the N. lactamica isolates were genetically diverse, with 69 distinct genotypes recovered from the 75 infants.
The Diversity of Meningococcal Carriage Across the African Meningitis Belt and the Impact of Vaccination With a Group A Meningococcal Conjugate Vaccine
TLDR
The prevalence of meningococcal carriage in the African meningitis belt is lower than in industrialized countries and is very diverse and dynamic, even in the absence of vaccination.
Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06
TLDR
The three Neisseria species groups represent coherent biological and genetic groupings which appear to be maintained by low rates of inter-species horizontal genetic exchange within the core genome.
A common gene pool for the Neisseria FetA antigen.
TLDR
Identical fetA variable region sequences were identified among commensal and pathogenic Neisseria, suggesting a common gene pool, differing from other antigens in this respect, suggesting the development of natural immunity to meningococcal disease.
Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences
TLDR
The suggestion that high frequency antigenic variation of pilin is not universal in pathogenic Neisseria is supported, as it is confirmed that meningococcal strains belonging to a limited number of clonal complexes harbour a class II pilE gene which is conserved in terms of sequence and chromosomal context.
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