Julia S. El-Sayed Moustafa

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Although genome-wide association studies have uncovered single-nucleotide polymorphisms (SNPs) associated with complex disease, these variants account for a small portion of heritability. Some contribution to this 'missing heritability' may come from copy-number variants (CNVs), in particular rare CNVs; but assessment of this contribution remains(More)
Childhood obesity is a major public health problem in Mexico, affecting one in every three children. Genome-wide association studies identified genetic variants associated with childhood obesity, but a large missing heritability remains to be elucidated. We have recently shown a strong association between a highly polymorphic copy number variant(More)
UNLABELLED A program package to enable genome-wide association of copy number variants (CNVs) with quantitative phenotypes in families of arbitrary size and complexity. Intensity signals that act as proxies for the number of copies are modeled in a variance component framework and association with traits is assessed through formal likelihood testing. (More)
R. G. Walters1,2,*, S. Jacquemont3,*, A. Valsesia4,6, A. J. de Smith1, D. Martinet3, J. Andersson1, M. Falchi1, F. Chen7, J. Andrieux8, S. Lobbens9, B. Delobel10, F. Stutzmann9, J. S. El-Sayed Moustafa1, J.-C. Chèvre9, C. Lecoeur9, V. Vatin9, S. Bouquillon8, J. L. Buxton1, O. Boute11, M. Holder-Espinasse11, J.-M. Cuisset12, M.-P. Lemaitre12, A.-E.(More)
Low serum salivary amylase levels have been associated with a range of metabolic abnormalities, including obesity and insulin resistance. We recently suggested that a low copy number at the AMY1 gene, associated with lower enzyme levels, also increases susceptibility to obesity. To advance our understanding of the effect of AMY1 copy number variation on(More)
BACKGROUND The accurate assignment of alleles embedded within trisomic or duplicated regions is an essential prerequisite for assessing the combined effects of single-nucleotide polymorphisms (SNPs) and genomic copy number. Such an integrated analysis is challenging because heterozygotes for such a SNP may be one of 2 genotypes-AAB or ABB. Established(More)
A two-element phased antenna array for a mobile handset is investigated using the Finite Difference Time Domain (FDTD) method. The array is designed to provide a spatial null in the near field zone in the direction of the human head. The optimisation algorithm to obtain the minimum peak specific absorption rate (SAR) is addressed. The dynamic range of the(More)
Objective: To compare between Gates GFR measurement using 99m Tc DTPA scintigraphy (in vivo method) as compared to in vitro blood sampling method (single and dual blood samples).Patients and methods: this prospective study included 40 normal individuals (group 1) and 40 patients with obstructive uropathy (group2) .The age of the group 1 ranging from: 22 to(More)
Erratum. Metabolomic Profile of Low–Copy Number Carriers at the Salivary a-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production. Diabetes 2016;65:3362–3368 DOI: 10.2337/db17-er04a Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, D.E.S.I.R. Study Group, Jean Tichet, Beverley Balkau, Thierry Brousseau,(More)
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