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  • Julia Riede, Birk Poller, Ken-Ichi Umehara, Joerg Huwyler, Gian P. Camenisch
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2016 (First Published: 1 April 2016)
  • Total human clearance is a key determinant for the pharmacokinetic behavior of drug candidates. Our group recently introduced the Extended Clearance Model (ECM) as an accurate in vitro-in vivoContinue Reading
  • Julia Riede, Ken-Ichi Umehara, +4 authors Birk Poller
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2019 (First Published: 1 April 2019)
  • ABSTRACT The generation of reliable kinetic parameters to describe P‐glycoprotein (P‐gp) activity is essential for predicting the impact of efflux transport on gastrointestinal drug absorption. TheContinue Reading