Julia Malcolm

Learn More
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice(More)
Early reperfusion after coronary artery occlusion is used to treat acute myocardial infarction, but the factors that determine whether salvage of ischaemic myocardium actually occurs remain poorly defined. Differences in collateral blood flow to the region at risk, and haemodynamic variables during occlusion, may contribute to uncertainty as to the time(More)
1. The respiratory role of the ventral surface of the medulla was studied in rats anaesthetized with a urethane-chloralose mixture. 2. In fifty-eight studies on twelve animals, direct superfusion of the medullary surface with artificial c.s.f. made acid by the reduction of bicarbonate content or by the increase of PCO2 produced no significant stimulation of(More)