Julia Lin

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Given recent adaptations of the World Health Organization's World Mental Health Composite International Diagnostic Interview (WMH-CIDI), new methodological studies are needed to evaluate the concordance of CIDI diagnoses with clinical diagnostic interviews. This paper summarizes lessons learned from a clinical reappraisal study done with US Latinos. We(More)
We propose nested latent compliance class models in the Imbens and Rubin (1997) compliance model framework for analyzing longitudinal randomized trials when subjects do not always adhere to the treatment to which they are randomized, and treatment adherence may vary over time. Traditional " intention-to-treat " and " as-treated " analyses may produce biased(More)
One of the most common challenges in biomedical and psychosocial research is missing data, which occurs when respondents refuse to provide answers to sensitive questions and when study subjects are lost to follow-up during the repeated assessments of longitudinal trials. This paper is the first in a 3-part series focusing on this important topic; it(More)
Power and sample size estimation constitutes an important component of designing and planning modern scientific studies. It provides information for assessing the feasibility of a study to detect treatment effects and for estimating the resources needed to conduct the project. This tutorial discusses the basic concepts of power analysis and the major(More)
SUMMARY A data monitoring committee (DMC) is a group of clinicians and biostatisticians appointed by study sponsors who provide independent assessment of the safety, scientific validity and integrity of clinical trials. In the United States, the Food and Drug Administration requires the formation of DMC in all trials that assess new interventions. DMC are(More)
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