Julia Lehtinen

Learn More
BACKGROUND Epidermal growth factor receptor (EGFR) is overexpressed in many solid tumor types, such as ovarian carcinoma. Immunoliposome based drug targeting has shown promising results in drug delivery to the tumors. However, the ratio of tumor-to-normal tissue concentrations should be increased to minimize the adverse effects of cytostatic drugs. (More)
The cell membrane is a gateway to the cell and immersion point for membrane proteins and thus is of interest for pharmacology and structural biology. This thesis aims to study its interaction with water, small molecules, polymers and proteins through molecular dynamics simulation and statistical analysis. In the first part of the thesis, I have performed a(More)
  • 1