152255 (E-1,1'-(2-butene-1,4-diyl)bis[2-[4-[3-(1-piperidinyl)propoxy]-phe nyl]-1H-benzimidazole]) exhibited high affinity (Ki = 12.7 nM) for human dopamine (DA) D3 receptors expressed in CHO K1 cells but not for DA D2L receptors (Ki = 565 nM), DA D42 or DA D1 receptors (Ki > 3 microM) and a number of other neurotransmitter receptors. Affinity for human… (More)
Liquid chromatographic-mass spectrometric (LC-MS) analysis of plasma taken from cynomolgus monkeys dosed orally with (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (1), a dopamine (DA) autoreceptor agonist and potential antipsychotic agent, revealed several metabolites. The molecular masses of three major metabolites… (More)
By examining the effect of dopamine (DA) D3 receptor stimulation on locomotor activity and extracellular levels of DA in striatum we show that inhibition of locomotor activity induced by DA D3 receptor-selective agonists is mediated by two interacting mechanisms: (1) directly via the stimulation of DA D3 receptors that inhibit locomotor activity, and (2)… (More)
In the current experiment, we simulated a multitasking environment and evaluated the effects of an intelligent agent, RoboLeader, on the performance of human operators who had the responsibility of managing the plans/routes for three vehicles (their own manned ground vehicle, an aerial robotic vehicle, and a ground robotic vehicle) while maintaining proper… (More)
Past research has shown that multi-modal sensory cues can reduce the workload of the user while simultaneously increasing performance capacity. This study looks to examine how performance is impacted in a multi-modal sensory cueing target detection task in which the cueing automation is imperfect. Twenty-seven undergraduate participants volunteered to take… (More)
To date, research into the potential impact of fundamental design attributes, such as material and color, on human-robot trust has been limited. This study addresses how a human's perception of fundamental, basic design features (i.e., the robot's physical appearance) may influence their attribution of anthropomorphic characteristics to the robot. Two… (More)
4-Benzyl-1-[4-(1H-imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent antagonist of the NR1A/2B subtype of the NMDA receptor. When dosed orally, this compound potentiates the effects of L-DOPA in the 6-hydroxydopamine-lesioned rat, a model of Parkinson's disease.