Julia L. Bienias

Learn More
CONTEXT Current and future estimates of Alzheimer disease (AD) are essential for public health planning. OBJECTIVE To provide prevalence estimates of AD for the US population from 2000 through 2050. DESIGN Alzheimer disease incidence estimates from a population-based, biracial, urban study, using a stratified random sampling design, were converted to(More)
BACKGROUND Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease. OBJECTIVE To examine whether fish consumption and intake of different types of n-3 fatty acids protect against Alzheimer disease. DESIGN Prospective study conducted(More)
CONTEXT Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking. OBJECTIVE To test the hypothesis that frequent participation in cognitive activities is associated with a reduced risk of AD. DESIGN Longitudinal cohort study with(More)
Results: In 2000, there were 4.5 million persons with AD in the US population. By 2050, this number will increase by almost 3-fold, to 13.2 million. Owing to the rapid growth of the oldest age groups of the US population, the number who are 85 years and older will more than quadruple to 8.0 million. The number who are 75 to 84 years old will double to 4.8(More)
BACKGROUND Few prospective studies have assessed diabetes mellitus as a risk factor for incident Alzheimer disease (AD) and decline in cognitive function. OBJECTIVE To evaluate the association of diabetes mellitus with risk of AD and change in different cognitive systems. DESIGN Longitudinal cohort study. PARTICIPANTS For up to 9 years, 824 older(More)
CONTEXT Sex differences in risk of clinically diagnosed Alzheimer disease (AD) have been studied extensively, but little is known about the relation of the pathologic indices of AD to the clinical manifestations of the disease in men compared with women. OBJECTIVE To test whether the relation of AD pathology to the clinical manifestations of the disease(More)
OBJECTIVES To examine the extent to which persons with mild cognitive impairment have intermediate levels of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body disease. METHODS A total of 180 Catholic clergy participating in the Religious Orders Study underwent annual detailed evaluation and brain autopsy. Blocks of midfrontal, superior(More)
The long-term objective of the Rush Memory and Aging Project is to identify the postmortem indices linking genetic and environmental risk factors to the development of Alzheimer's disease (AD). The overall study design involves a detailed assessment of risk factors for AD in older persons without known dementia who agree to annual clinical evaluation and(More)
We determined whether oxidative stress is an early event in the pathogenesis of sporadic Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions and neurofibrillary pathology in AD and mild cognitive impairment (MCI). Oxidative stress was measured as the percentage of astrocytes expressing heme oxygenase-1 (HO-1) in post(More)
OBJECTIVE To examine the relation of social resources and cognitive decline in older adults. METHODS Data are from the Chicago Health and Aging Project, an epidemiologic study of risk factors for Alzheimer disease (AD) and other common conditions in a geographically defined population of older persons. The sample consisted of 6,102 non-Hispanic African(More)