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A substantial body of research has investigated the effects of work on the psychological well-being of employees. However, there has been little assessment of the ways in which workplace factors (such as job demands, working conditions, inter-personal relations and workplace change) interact with personal factors (such as work-life balance, family(More)
OBJECTIVES To identify plausible mechanisms by which resilience (low mortality rates despite persistent economic adversity) was achieved in some areas in Britain between 1971 and 2001. METHODS Mixed method observational study, combining quantitative analyses of cause- and age group-specific mortality rates, and area sociodemographic and environmental(More)
OBJECTIVE Two unrelated families were ascertained in which sisters had infantile onset of epilepsy and developmental delay. Mutations in the protocadherin 19 (PCDH19) gene cause epilepsy and mental retardation limited to females (EFMR). Despite both sister pairs having a PCDH19 mutation, neither parent in each family was a heterozygous carrier of the(More)
OBJECTIVE To determine factors that predict change in walking velocity in older people using a multivariate model. DESIGN Longitudinal observational study. SUBJECTS A total of 588 persons older than age 60, including subjects residing in a continuing care retirement community (CCRC) (n = 248), and homebound (n = 79) and ambulatory (n = 261) subjects.(More)
OBJECTIVE To determine factors that predict decline in manual performance using a multivariate model of determinants of functional limitation. DESIGN Longitudinal observational study. SETTINGS Ambulatory general medicine clinics, residences of homebound individuals, and a continuing care retirement community. PARTICIPANTS Subjects were 485 persons(More)
OBJECTIVE To validate a hierarchical model of hand function in older persons, using longitudinal data. DESIGN Longitudinal observational study (2-year data from an ongoing longitudinal study). SUBJECTS 689 persons older than age 60, including Continuing Care Retirement Community (n = 230), homebound (n = 204), and ambulatory (n = 255) respondents. Mean(More)
OBJECTIVE To test the impact of joint impairment on ambulation in the elderly, using a multivariate model. DESIGN Cross-sectional observational study (baseline data from an ongoing longitudinal study). SUBJECTS Five hundred thirty-two persons over age 60, including continuing care retirement community (CCRC) (n = 222), homebound (n = 63), and ambulatory(More)
OBJECTIVES To identify areas of Britain whose residents have relatively low age specific mortality, despite experiencing long-term economic adversity. METHODS Longitudinal, ecological study of all residents of Britain from 1971 to 2001. RESULTS 54 of Britain's 641 parliamentary constituencies were identified as having been persistently economically(More)
OBJECTIVE To determine predictors of walking velocity in the elderly. METHODS Five hundred thirty-two persons from 3 cohorts of elderly persons (retirement community, ambulatory care medical clinic, or chronically homebound population) performed a 10-foot (for the homebound subjects) or 50-foot (for all other subjects) walk time test and underwent a(More)
OBJECTIVE To test the contribution of joint impairment to observed hand function (grip strength and Williams Test) in the elderly, using a multivariate model. DESIGN Cross-sectional observational data (baseline data from an ongoing longitudinal study). SUBJECTS Five hundred forty-one persons over age 60, including continuing care retirement community (n(More)