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Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs.(More)
Discrimination of the change in rate of sinusoidal amplitude modulation was investigated for sinusoidal carriers. The just-noticeable change in the modulation rate was measured as a function of (1) carrier frequency (fc = 500, 1000, 2000, or 4000 Hz), (2) initial modulation rate (fm = 10, 20, 40, 80, 160, or 320 Hz), and (3) stimulus duration (T = 62, 125,(More)
The ability to detect a mistuned component in a harmonic complex was measured as a function of harmonic number under three different stimulus procedures: simultaneous monotic, successive monotic, and simultaneous dichotic. In the first experiment, the fundamental frequency was 200 Hz, and the stimulus duration was 410 ms. The threshold obtained in the(More)
We present detailed evidence for a warm absorber in the Seyfert 1 galaxy MCG–6-30-15 and dispute earlier claims for relativistic O line emission. The HETG spectra show numerous narrow, unresolved (FWHM ∼ < 200 km s −1) absorption lines from a wide range of ionization states of N edge and 1s 2 − 1snp resonance line series to n = 9 are clearly detected at(More)
We present X-ray, infrared, optical and radio observations of four previously unidentified Galactic plane X-ray sources, AX J163252–4746, AX J184738–0156, AX J144701–5919 and AX J144547–5931. Detection of each source with the Chandra X-ray Observatory has provided sub-arcsecond localizations, which we use to identify bright infrared counterparts to all four(More)
We present analyses of a 50 ks observation of the supergiant X-ray binary system Cygnus X-1/HDE 226868 taken with the Chandra High Energy Transmission Grating Spectrometer (HETGS). Cyg X-1 was in its spectrally hard state and the observation was performed during superior conjunction of the black hole, allowing for the spectroscopic analysis of the accreted(More)
We present X-ray dust scattering halo results based on our 76 ks Chandra ACIS-S/HETGS observation of the LMXB dipping source 4U 1624-490. Through analysis of the halo light curves with 2-6 keV spectra over the persistent and dipping periods, we estimate a geometric distance of ∼15 kpc to 4U 1624-490. We also fit halo radial profiles with different ISM dust(More)
We present detailed evidence for a warm absorber in the Seyfert 1 galaxy MCG–6-30-15 and refute earlier claims for relativistic O line emission. The HETG spectra show numerous absorption lines from a wide range 2 − 1snp resonance line series to n = 9 are clearly detected at rest in the AGN frame. We attribute previous reports of an apparently highly(More)