Julián Rodríguez-López

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A novel hybrid dendrimer (TRANSGEDEN) that combines a conjugated rigid polyphenylenevinylene (PPV) core with flexible polyamidoamine (PAMAM) branches at the surface was synthesized and characterized. The potential of this material as a nonviral gene delivery system was also examined, and it was observed that dendriplexes formed by TRANSGEDEN and small(More)
The synthesis of a series of push-pull arylvinyl (styryl), aryl, and arylethynyl quinazoline derivatives by means of different straightforward protocols is reported. The photophysical properties of the compounds are described. The preparation of arylvinylquinazolines was performed by aldol condensation of the appropriate methylquinazoline and functionalized(More)
A series of V-shaped 4,6-bis(arylvinyl)pyrimidines have been efficiently prepared by aldol condensation between 4,6-dimethylpyrimidine and the appropriate aromatic aldehyde. The methodology also proved successful when dendritic first generation poly(phenylenevinylene) aldehydes were used. Moreover, asymmetrically functionalized molecules were also obtained(More)
A series of 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines have been efficiently prepared by a double cross-coupling reaction between 2,4-dichloro-6-methylpyrimidine and 2-(tributylstannyl)pyridine, followed by aldol condensation with the appropriate aromatic aldehyde substituted with electron-donating, electron-withdrawing, dendritic, or water-soluble groups.(More)
New dipolar and non-dipolar poly(phenylenevinylene) dendrimers bearing electron-donating and electron-withdrawing groups have been efficiently synthesized using Heck and Horner-Wadsworth-Emmons reactions. The photoluminescence of these systems may be tuned in the blue zone by choosing the appropriate peripheral groups. Despite the meta-substitution pattern,(More)
We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
The efficient synthesis of new asymmetric poly(phenylenevinylene) dendritic macromolecules using a stepwise convergent-growth approach is described. By an iterative methodology that made use of the Horner-Wadsworth-Emmons (HWE) reaction, dendrons and dendrimers up to the third generation, with eight different functional groups located at the periphery, were(More)
A boost from the branches: Incorporation of the dithieno[3,2-b:2',3'-d]phosphole system as a core in oligo(phenylenevinylene) dendrimers (an example is shown here) provides materials that exhibit energy-transfer features relaying incoming photons from the dendrons towards the core, which in turn shows enhanced emission intensity. The optical properties and(More)
An extensive study by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) of some first-generation and second-generation lanthanide(III)-cored poly(phenylenevinylene) dendrimers is described. The complexes were obtained by self-assembly of suitably functionalized carboxylate dendrons around the lanthanide ion(More)
New chiral, soluble binaphthyl derivatives that incorporate stilbenoid dendrons at the 6,6'-positions have been prepared. The synthesis of the new enantiopure dendrimers was performed in a convergent manner by Horner-Wadsworth-Emmons (HWE) reaction of the appropriately functionalized 1,1'-binaphthyl derivative (R)-1 and the appropriate dendrons(More)