Julián Domínguez

Learn More
 The aim of this study was to prospectively analyze the bacterial etiology of community-acquired pneumonia in adults in Spain. From May 1994 to February 1996, 392 episodes of CAP diagnosed in the emergency department of a 600-bed university hospital were studied. An etiological diagnosis based on noninvasive microbiological investigations was achieved in(More)
During infancy and childhood, clinical signs of infection and conventional laboratory markers are not specific in the early phase of disease [1]. The availability of a parameter that more rapidly identifies children suspected to have bacterial sepsis before microbiological results are available would minimize unnecessary treatments and hospitalization.(More)
 The performance was evaluated of a fluorescence in situ hybridisation assay using peptide nucleic acid probes (Dako Probe MTB Culture Confirmation Test; Dako, Denmark) for identification of Mycobacterium tuberculosis complex (MTC) organisms and differentiation between tuberculous and non-tuberculous mycobacteria (NTM) in material taken directly from Bactec(More)
The aim of this study was to determine the duration of Streptoccocus pneumoniae antigen excretion in urine after pneumococcal pneumonia. Urinary antigen detection remained positive in nonconcentrated urine in 18 (52.9%) of the 34 patients in the first month after pneumonia diagnosis. In 12 of these positive cases, the test was still positive in the second(More)
 A new immunochromatographic membrane assay for detecting Legionella pneumophila serogroup 1 antigen in urine samples (Binax Now Legionella Urinary Antigen Test; Binax, USA) was evaluated. Its sensitivity, specificity and level of agreement with the Binax enzyme immunoassay were compared using nonconcentrated and concentrated urine samples. The overall(More)
The aim of this study was to investigate whether procalcitonin (PCT), neopterin, C-reactive protein (CRP), and mid regional pro-atrial natriuretic peptide (MR-proANP) levels at admission and during the clinical course can be useful for the management of patients with pneumonia. The study population consisted of 75 patients with clinical and radiological(More)
Two commercial systems for the amplification and detection ofMycobacterium tuberculosis directly from respiratory samples were compared. The Roche Cobas Amplicor MTB Test and the Roche manual Amplicor MTB Test (Roche Diagnostic Systems, USA) were applied to 755 decontaminated respiratory specimens collected from 470 patients. Results were compared with(More)
The aim of this prospective study was to compare patient characteristics, clinical data, and evolution of Legionella pneumophila pneumonia according to the duration of Legionella urinary antigen excretion. Urine samples from 61 patients with Legionella pneumonia diagnosed by detection of urinary antigen were obtained periodically until urinary antigen(More)
The availability of commercial urinary antigen tests increased the diagnosis of Legionnaires’ disease, and also decreased mortality, possibly as a result of obtaining an earlier diagnosis in the course of disease [1]. Detection of the Legionella pneumophila serogroup 1 soluble antigen in urine by the enzyme immunoassay (EIA) has proven to be rapid,(More)
The ability of a polymerase-chain-reaction-based technique combined with a reverse hybridisation line-probe assay to detect and identify eight of the most clinically significant mycobacterial species directly from cultures in liquid medium was evaluated. The line-probe assay allows simultaneous identification of eight different mycobacterial species.(More)