Jules Thibault

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Abstract: Artificial Neural Network (ANN) techniques are applied to the control of coagulant dosing in a drinking water treatment plant. Coagulant dosing rate is non-linearly correlated to raw water parameters such as turbidity, conductivity, pH, temperature, etc. An important requirement of the application is robustness of the system against erroneous(More)
The production of cellulase from the filamentous fungus Trichoderma reesei is a critical step in the industrial process leading to cellulose ethanol. As a result of the lack of quantitative analysis tools, the intimate relationship that exists between the morphological and physiological states of the microorganism, the shear field in the bioreactor, and the(More)
Two home, blood-glucose monitoring meters, OneTouch Ultra and Ascensia Contour, were used to determine the glucose concentration during fermentations of Trichoderma reesei in both flasks and bioreactors. The results, when compared to those given by the 3,5-dinitrosalicylic acid reducing sugar assay, HPLC and YSI 2700 SELECT Biochemistry analyzer, showed(More)
The feasibility of pressurized culture was explored for the growth of Aureobasidium pullulans and the synthesis of pullulan. For all volumetric flow rates of air, the production of biomass increased with pressure up to a critical value ranging from 0.50 to 0.75 MPa, at which point a drastic decrease in biomass production and a change in cellular morphology(More)
Human 293S cells culture for recombinant adenovirus production is traditionally carried out in batch at a maximum of 6 x 10(5) cells/mL. A previous report demonstrated that fed-batch, applied to the adenovirus/293S cells system, improves the volumetric production of viral proteins by increasing the cell density at which cells can be infected, up to 2 x(More)
Fermentation experiments using Aspergillus niger result in a very viscous broth due to the growth of filamentous microorganism. For viscous fermentation processes, it is difficult to estimate with confidence the volumetric oxygen mass transfer coefficient (K(L)a), which can be used for scale-up or design of bioreactors. In the present study, four methods(More)
A rotational reciprocating plate impeller prototype, designed to improve the mixing homogeneity of viscous non-Newtonian fermentation broth, has been tested in pullulan fermentations. With this new impeller, the operating levels of several factors were investigated to improve pullulan production with Aureobasidium pullulans ATCC 42023 in a 22-L bioreactor(More)
The biochemical process industry is often confronted with the challenge of making decisions in an atmosphere of multiple and conflicting objectives. Recent innovations in the field of operations research and systems science have yielded rigorous multicriteria optimization techniques that can be successfully applied to the field of biochemical engineering.(More)