Jules L. Griffin

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Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and is reversed in failing adult hearts,(More)
Five anesthetized dogs undertook a chamber dive, on air, to 300 feet of seawater for 15 min. After the dive, spinal cord decompression sickness was detected by recording a reduced amplitude of the somatosensory evoked potential compared with predive base-line values. After the diagnosis of decompression sickness and rapid perfusion fixation of the animal,(More)
min E deficiency and metabolic deficits in neuronal ceroid lipofuscinosis described by bioinformatics.—The mnd mouse, a model of neuronal ceroid lipofusinosis (NCL), has a profound vitamin E deficiency in sera and brain, associated with cere-bral deterioration characteristic of NCL. In this study, the vitamin E deficiency is corrected using dietary(More)
BACKGROUND/OBJECTIVES Obesity has been associated with both changes in adipose tissue lipid metabolism and inflammation. A key class of lipid-derived signalling molecules involved in inflammation are the prostaglandins. In this study, we aimed to determine how obesity affects the levels of prostaglandins within white adipose tissue (WAT) and determine which(More)
BACKGROUND Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-derived epoxyeicosatrienoic acid (EET)-mediated endothelial function is impaired in patients with COPD and that a novel soluble epoxide hydrolase inhibitor, GSK2256294, attenuates(More)
METAtarget is an ew method forr everse engineeringo fm etabolic networks andthe detectionoftargets enzymes from high-throughputmetabolomics data.U sing KEGG REACTION, reactantp artnersa re identifieda nd ther atio of productt os ubstratem etabolite concentrations is employed as surrogate fort he reactiona ctivity.Atest statisticsi si ntroduced to assess(More)
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