Jules Horowitz

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The growth of T lymphocytes is dependent on the T-cell growth factor interleukin 2 (IL-2), which causes T cells bearing high-affinity receptors for IL-2 to proliferate. Most cloned helper-T-cell lines can be shown to both produce and respond to IL-2; thus, growth of such cells is by an autocrine mechanism. We report that the failure of the cloned murine(More)
The growth factor requirements of cloned lines representing two major subsets of CD4+ T cells were examined. The helper subset, which produces IL-4 as its autocrine growth factor, proliferates in response to IL-2 or to IL-4 in the presence of IL-1. The inflammatory subset, which produces IL-2 as its autocrine growth factor, proliferates in response to IL-2(More)
Calculation of the therapeutic activity of radioiodine (131)I for individualized dosimetry in the treatment of Graves' disease requires an accurate estimate of the thyroid absorbed radiation dose based on a tracer activity administration of (131)I. Common approaches (Marinelli-Quimby formula, MIRD algorithm) use, respectively, the effective half-life of(More)
Many end stage renal disease (ESRD) patients suffer from anemia due to insufficient endogenous production of erythropoietin (EPO). The discovery of recombinant human EPO (rHuEPO) over 30 years ago has shifted the treatment of anemia for patients on dialysis from blood transfusions to rHuEPO therapy. Many anemia management protocols (AMPs) used by clinicians(More)
Vocal fold paralysis most commonly results from injury to the recurrent laryngeal nerve. The length of time required for denervation atrophy would be useful in planning reinnervation procedures. Given the absence of long-term data on the status of the canine posterior cricoarytenoid muscle following denervation, this study was undertaken. The results(More)
Multiprocessor system-on-a-chip (SoC) platforms are ideal hardware platforms for implementing nowadays-complex telecommunication, automotive and network applications. Nevertheless, the design and verification of such applications requires a high degree of automation because the configuration of all the parameters for the hardware platform and the embedded(More)
Results are presented studying the contribution of particle toughening to impact damage resistance in carbon fibre reinforced polymer materials. Micro-focus X-ray computed tomography and synchrotron radiation computed laminography were used to provide a novel, multiscale approach for assessing impact damage. Thin (1mm thick) composite plates containing(More)
Different cell types in the immune system appear to mediate their effects by markedly different means. B lymphocytes couple information for specificity with information for function in a single long-range molecule, antibody. Major histocompatibility complex (MHC)-restricted T cells, which we have analyzed in detail, appear to recognize antigen only on the(More)
1. Introduction. The discovery by Willinger et. al. that the input process to an Ethernet cable exhibits, at least empirically, long range dependence (LRD) and self-similarity has produced many models of this phenomenon, along with many, sometimes ad-hoc, statistical methods to analyze them ([1],[5],[14],[17]). It has been observed, for example, that(More)