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OBJECTIVE To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients. DESIGN Prospective, multicenter study. SETTING Forty intensive care units (ICUs) in 16 countries. PATIENTS Patients admitted to the ICU in May 1995 (n = 1,449), excluding(More)
OBJECTIVE To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in patients with septic shock. The predefined primary efficacy objective was survival at day 28. DESIGN Multiple-center, randomized, two-stage, double-blind, placebo-controlled, safety and efficacy study. SETTING A total of 124 intensive care units in Europe, North(More)
We report about new apoptotic and non-apoptotic death pathways in neutrophils that are initiated via the surface molecule sialic acid-binding immunoglobulin-like lectin (Siglec)-9. In normal neutrophils, Siglec-9 ligation induced apoptosis. Inflammatory neutrophils obtained from patients with acute septic shock or rheumatoid arthritis demonstrated increased(More)
Data on occupational accidents are not available from all countries in the world. Furthermore, underreporting, limited coverage by reporting and compensation schemes, and non-harmonized accident recording and notification systems undermine efforts to obtain worldwide information on occupational accidents. This paper presents a method and new estimated(More)
  • J Takala
  • 1999
Every year 335,000 workers die in occupational accidents and altogether 1.1 million fatalities are caused by work-related factors. Some 250 million nonfatal accidents causing absence from work are aggravated by permanent disabilities, reduced capacity of life and work, and economic losses amounting to 4% of gross national product. The role of the(More)
This article reviews the present indicators, trends, and recent solutions and strategies to tackle major global and country problems in safety and health at work. The article is based on the Yant Award Lecture of the American Industrial Hygiene Association (AIHA) at its 2013 Congress. We reviewed employment figures, mortality rates, occupational burden of(More)
CONTEXT Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an α(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort. OBJECTIVE To determine the efficacy of dexmedetomidine vs midazolam or propofol (preferred usual care)(More)
OBJECTIVE To evaluate the performance of total maximum sequential organ failure assessment (SOFA) score and a derived measure, delta SOFA (total maximum SOFA score minus admission total SOFA) as a descriptor of multiple organ dysfunction/failure in intensive care. DESIGN Prospective, multicentre and multinational study. SETTING Forty intensive care(More)