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  • Jukka Kervinen, Gregory J. Tobin, Júlia Duarte Costa, David S Waugh, Alexander Wlodawer, Alexander S. Zdanov
  • Medicine, Biology
  • The EMBO journal
  • 1999 (First Publication: 15 July 1999)
  • We determined at 2.3 A resolution the crystal structure of prophytepsin, a zymogen of a barley vacuolar aspartic proteinase. In addition to the classical pepsin-like bilobal main body of phytepsin,Expand
  • Jukka Kervinen, Roland L. Dunbrack, +6 authors Eileen K Jaffe
  • Chemistry, Medicine
  • Biochemistry
  • 2000 (First Publication: 1 August 2000)
  • Porphobilinogen synthase (PBGS) is present in all organisms that synthesize tetrapyrroles such as heme, chlorophyll, and vitamin B(12). The homooctameric metalloenzyme catalyzes the condensation ofExpand
  • Jukka Kervinen, Eileen K Jaffe, Frederic R. Stauffer, Reinhard Neier, Alexander Wlodawer, Alexander S. Zdanov
  • Chemistry, Medicine
  • Biochemistry
  • 2001 (First Publication: 1 July 2001)
  • 4,7-Dioxosebacic acid (4,7-DOSA) is an active site-directed irreversible inhibitor of porphobilinogen synthase (PBGS). PBGS catalyzes the first common step in the biosynthesis of the tetrapyrroleExpand
  • Jukka Kervinen, Jacek Lubkowski, +7 authors Alla Gustchina
  • Medicine, Chemistry
  • Protein science : a publication of the Protein…
  • 1998 (First Publication: 1 November 1998)
  • One of the major problems encountered in antiviral therapy against AIDS is the emergence of viral variants that exhibit drug resistance. The sequences of proteases (PRs) from related retrovirusesExpand