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We propose a novel convex relaxation of sparse principal subspace estimation based on the convex hull of rank-d projection matrices (the Fantope). The convex problem can be solved efficiently using alternating direction method of multipliers (ADMM). We establish a near-optimal convergence rate, in terms of the sparsity, ambient dimension, and sample size,(More)
INTRODUCTION Although it is known that at comparable body mass index (BMI) levels Asian Americans have a higher prevalence of high blood pressure, heart disease, and type 2 diabetes than whites, little is known about the social, behavioral, and cultural factors associated with obesity risk in this population. METHODS A cross-sectional analysis of the 2003(More)
STUDY OBJECTIVE To compare cosmetic satisfaction with laparoendoscopic single-site surgery (LESS) compared with multi-port surgery. DESIGN Randomized controlled trial (Canadian Task Force classification I). SETTING University hospital. PATIENTS Twenty women who underwent laparoscopically-assisted vaginal hysterectomy (LAVH) via LESS or multi-port(More)
BACKGROUND The association between serum bilirubin levels and incident chronic kidney disease (CKD) in the general population is unknown. We aimed to examine the association between serum bilirubin concentration (total, direct, and indirect) and the risk of incident CKD. METHODS AND FINDINGS Longitudinal cohort study of 12,823 Korean male workers 30 to 59(More)
We investigated the impacts of breast cancer diagnosis and treatment on employment status and the ability to perform occupational and housekeeping tasks. We performed a cross-sectional study to compare Korean breast cancer survivors (n = 1,594) who had been working before cancer diagnosis with a group of 20 to 60-year-old women from the general Korean(More)
OBJECTIVES There is suggestive but sparse evidence that dyslipidemia is associated with colorectal neoplasms. We investigated the association of serum lipid and apolipoprotein concentrations with the prevalence of colorectal adenomas. METHODS Cross-sectional study of 19,281 consecutive participants aged 40-79 years undergoing screening colonoscopy at the(More)
BACKGROUND The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. OBJECTIVE To investigate the risk for incident CKD across categories of body mass index in a large cohort of metabolically healthy men and women. DESIGN Prospective cohort(More)
Genetic information presents challenges to all patients, but particularly those with low and marginal literacy. The goal of the study was to create a rapid estimate of adult literacy in genetics (REAL-G) tool, with established validity, for use with patients receiving genetics services. Patterned after the widely used rapid estimate of adult literacy in(More)
BACKGROUND & AIMS The goal of this study was to examine the association of sitting time and physical activity level with non-alcoholic fatty liver disease (NAFLD) in Korean men and women and to explore whether any observed associations were mediated by adiposity. METHODS A cross-sectional study was performed on 139,056 Koreans, who underwent a health(More)
Personality is a determinant of behavior and lifestyle associated with health and human diseases. Although personality is known to be a heritable trait, its polygenic nature has made the identification of genetic variants elusive. We performed a genome-wide association study on 1089 Korean women aged 18-40 years whose personality traits were measured with(More)