Juha Karvanen

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Recently, genome wide association studies (GWAS) have identified a number of single nucleotide polymorphisms (SNPs) as being associated with coronary heart disease (CHD). We estimated the effect of these SNPs on incident CHD, stroke and total mortality in the prospective cohorts of the MORGAM Project. We studied cohorts from Finland, Sweden, France and(More)
BACKGROUND Cardiovascular disease (CVD) incidence, complications and burden differ markedly between women and men. Although there is variation in the distribution of lifestyle factors between the genders, they do not fully explain the differences in CVD incidence and suggest the existence of gender-specific genetic risk factors. We aimed to estimate whether(More)
In this paper sparseness measures are reviewed, extended and compared. Special attention is paid on measuring sparseness of noisy data. We review and extend several definitions and measures for sparseness, including the , p and norms. A measure based on order statistics is also proposed. The concept of sparseness is extended to the case where a signal has a(More)
We introduce a mutual information-based method for blind separation of statistically independent source signals. The Pearson system is used as a parametric model. Starting from the de.nition of mutual information we show using the results by Pham (IEEE Trans. Signal Process. 44(11) (1996) 2768–2779) that the minimization of mutual information contrast leads(More)
We study the optimal design of switching measurements of small Josephson junction circuits which operate in the macroscopic quantum tunnelling regime. Starting from the D-optimality criterion we derive the optimal design for the estimation of the unknown parameters of the underlying Gumbel type distribution. As a practical method for the measurements, we(More)
The generalized lambda distribution (GLD) is a flexible four parameter distribution with many practical applications. L-moments of the GLD can be expressed in closed form and are good alternatives for the central moments. The L-moments of the GLD up to an arbitrary order are presented, and a study of L-skewness and L-kurtosis that can be achieved by the GLD(More)
When carefully planned and analysed, the case-cohort design is a powerful choice for follow-up studies with multiple event types of interest. While the literature is rich with analysis methods for case-cohort data, little is written about the designing of a case-cohort study. Our experiences in designing, coordinating and analysing the MORGAM case-cohort(More)
Association of estrogen receptor 1 (ESR1) gene variants and risk of coronary heart disease (CHD) and ischemic stroke was evaluated in the FINRISK-study. From 14,140 individuals, 2225 were selected for genotyping using a case-cohort design. Time-to-event analysis showed that the CC genotype of -397T/C ERS1 gene contributed to higher risk of CHD only in men(More)