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BACKGROUND Shanxi Province has historically reported a high prevalence of NTDs. In order to establish baseline rates for NTDs and discuss the risk factors associated with sociodemographic, maternal characteristics, and geographic factors, we performed the present study using an approach combining population and hospital-based methodologies. METHODS We(More)
BACKGROUND The prevalence of neural tube defects (NTDs) in northern China is among the highest in the world. A massive folic acid supplementation program as a specific countermeasure was introduced in 2009. Examining trends in NTD prevalence may provide evidence for future intervention. METHODS Data for 2000 to 2014 in five counties in northern China were(More)
OBJECTIVE To evaluate changes in the age-adjusted prevalence of disability in transitional China from 1987 to 2006. METHODS Data from nationally representative surveys conducted in 1987 and 2006 were used to calculate age-adjusted disability prevalence rates by applying appropriate sample weights and directly adjusting to the age distribution of the 1990(More)
BACKGROUND Animal experiments indicate that prenatal exposure to mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) can induce fetal neural tube defects (NTDs). The objectives of this study were to determine the levels of maternal exposure to Hg, Pb, Cd and As during early pregnancy in rural areas of Shanxi Province, China, in order to explore factors(More)
UNLABELLED Maternal tea consumption was reported to increase the risk of fetal neural tube defects (NTDs). Catechol-O-methyltransferase (COMT) may be involved in the metabolism of polyphenolic methylation of tea, thus influence the risk of fetal NTDs. METHODS A total of 576 fetuses or newborns with NTDs and 594 healthy newborns were included in the(More)
AIM This article examines the prevalence of functional disability as well as sociodemographic correlations among Chinese older adults based on the most recent China National Sample Survey on Disability in 2006. METHODS Functional disability was defined as lost motor function or limited movements and activities according to the International Classification(More)
Methylenetetrahydrofolate reductase (MTHFR) C677T and catechol-O-Methyltransferase (COMT) G158A are associated with a risk of neural tube defects (NTDs) in offspring. This study examined the effect of a MTHFR × COMT interaction on the risk of NTDs in a Chinese population with a high prevalence of NTDs. A total of 576 fetuses or newborns with NTDs and 594(More)
OBJECTIVE To examine the influence of China's economic reforms on population health and regional mortality rates. METHODS Longitudinal study measuring the mortality trends and their regional variations. Using data from the three most recent national censuses, we used the model life table to adjust the mortality levels within the population for each(More)
OBJECTIVE This study evaluates trends in disability-free life expectancy (DFLE) of Chinese adults aged 60 and older. METHODS Based on two national disability surveys in 1987 and 2006 as well as mortality data from World Population Prospects, the Sullivan method was used to calculate DFLE. RESULTS DFLE increased from 13.0 to 13.9 years at age 60 and from(More)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and have been reported to be a risk factor for human neural tube defects (NTDs). We investigated the relationship between PAH concentrations in maternal serum and NTD risk in offspring using a case-control study design, and explored the link between PAH concentrations to(More)