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Induction of inducible nitric oxide synthase increases the production of reactive oxygen species in RAW264.7 macrophages.
The present study suggests that the induction of iNOS upregulates the PMA-induced assembly of NOX and leads to the enhanced production of ROS via a PKCzeta-dependent mechanism.
Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid‐β1–42
Pretreatment of microglia with melatonin dose‐dependently prevents the activation of NADPH oxidase and decreases the production of ROS, and offers new insights into the mechanism of inhibiting ROS generation by melatonin in Aβ‐activated microglIA.
Pushing the hyperpolarizability to the limit.
It is suggested that donor-acceptor molecules with a conjugated bridge with many sites of reduced conjugations to impart conjugation modulation may be the best paradigm for making materials with huge hyperpolarizabilities that approach the fundamental limit.
Two-photon fluorescence measurements of reversible photodegradation in a dye-doped polymer.
The energy dependence suggests that photodegradation is a linear process, while recovery is entropic, which could be useful to high-intensity devices such as two-photon absorbers, which can be used in many applications.
Optimizing potential energy functions for maximal intrinsic hyperpolarizability
We use numerical optimization to study the properties of (1) the class of one-dimensional potential energy functions and (2) systems of point nuclei in two dimensions that yield the largest intrinsic
Hardening of polymer optical materials with laser cycling and gamma-rays
When certain molecules are doped into polymers, they are photo-chemically more stable to photodegradation than the same molecule in liquid solution or crystalline form. Furthermore, such composite
Disruption of lipid rafts impairs the production of nitric oxide in lipopolysaccharide-stimulated murine RAW264.7 macrophages
Upon stimulation with lipopolysaccharide, murine RAW264.7 macrophages generated a high amount of nitric oxide and methyl-β-cyclodextrin exposure significantly inhibited the degradation of IκB-α, blocked the translocation of p65/RelA into the nuclei and prevented the activation of the NF-κB signaling pathway.
Intrinsic Hyperpolarizabilities as a Figure of Merit for Electro-optic Molecules
We propose the scale-invariant intrinsic hyperpolarizability as a measure of the figure of merit for electrooptic molecules. By applying our analysis to the best second-order nonlinear-optical
Continuous melt processing of all-polymer distributed feedback lasers
Novel processing techniques for low-cost production of photonic devices could open up new applications for functional polymer systems. To this end, we have used multilayer coextrusion in a continuous