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MicroRNAs play important roles in carcinogenesis by negatively regulating the expression of target genes. Here we explore the biological function of miR-155 and the underlying mechanism in colorectal carcinoma. We validate, for the first time, that E2F2 is a direct target of miR-155 using western blot and a luciferase reporter assay and that miR-155(More)
Helicobacter pylori (H. pylori) infection causes peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma. The eradication of H. pylori might be an effective means of preventing gastric cancer. A dual-antigen epitope and dual-adjuvant vaccine called CTB-UE-CF (CCF) was constructed by combining a multi-epitope vaccine(More)
Wireless sensor networks (WSNs) have great potential to revolutionize many science and engineering domains. We present a novel environmental monitoring system with a focus on overall system architecture for seamless integration of wired and wireless sensors for long-term, remote, and near-real-time monitoring. We also present a unified framework for sensor(More)
We propose a spatial autocorrelation aware, energy efficient, and error bounded framework for interpolating maps from sensor fields. Specifically, we propose an iterative reporting framework that utilizes spatial interpolation models to reduce communication costs and enforce error control. The framework employs a simple and low overhead in-network(More)
BACKGROUND Retrograde type A aortic dissection has been deemed a rare complication after endovascular stent graft placement for type B dissection. However, this life-threatening event appears to be underrecognized and is worth being investigated further. METHODS AND RESULTS Eleven of 443 patients developed retrograde type A aortic dissection during or(More)
Many studies have evaluated the associations between pre-diagnostic circulating C-reactive protein (CRP), interleukin-6 (IL-6) and colorectal cancer risk, but their results are inconsistent. We therefore conducted a meta-analysis to investigate these associations. A comprehensive literature search up to October 2013 was undertaken in PubMed. Pooled relative(More)
Environmental monitoring represents a major application domain for wireless sensor networks. In this paper, we present the design and implementation of low-power wireless sensor networks for long-term, autonomous, and near-real-time environmental monitoring applications. We have developed a suite of networking protocols to provide reliable data collection(More)
Wireless sensor networks (WSN) technology has great potential to revolutionize many science and engineering domains. We present a novel environmental monitoring system with a focus on the overall system architecture for seamless integration of wired and wireless sensors for long-term, remote, and near-real-time monitoring. We also present a unified(More)
Preoperative jaundice is frequent in gallbladder cancer (GBC) and indicates advanced disease. Resection is rarely recommended to treat advanced GBC. An aggressive surgical approach for advanced GBC remains lacking because of the association of this disease with serious postoperative complications and poor prognosis. This study aims to re-assess the(More)
AIM Multiple studies have revealed that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) is overexpressed in many cancers and facilitates tumor progression. However, the role of GIT1 in hepatocellular carcinoma (HCC) remains unclear. METHODS GIT1 expression was detected in cell lines and 130 pairs of HCC and matched adjacent noncancerous(More)