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Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression
TLDR
Pokemon promotes breast cancer progression by upregulating survivin expression and thus may be a potential target for the treatment of this malignancy.
Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities
TLDR
Two new furostanol saponins and three known compounds were isolated from the dry fruits of Tribulus terrestris and compounds 1–5 showed potential anti-tumour activity.
A syringe‐focused ultrasound device for simultaneous injection of DNA and gene transfer
TLDR
A novel syringe‐focused US device of the design is described that combines simultaneous DNA injection and US irradiation to resolve issues, achieving improved DNA uptake for high expression and lowering the incidence of tissue injury.
SP1 enhances Zbtb7A gene expression via direct binding to GC box in HePG2 cells
TLDR
It was found that the GC box within Zbtb7A promoter is necessary for the promoter activity and the physical interaction between Sp1 and GC box is responsible for the activation of ZbtB7A gene promoter.
Sine-wave current for efficient and safe in vivo gene transfer.
TLDR
It is demonstrated that efficient in vivo gene transfer could be safely achieved using pulses of alternating current sine-waves (ACSWs) with a frequency of 60 Hz and showed less toxicity than with conventional DC square-wave pulses.