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The vaccinia virus TianTan (VTT) has been modified as an HIV vaccine vector in China and has shown excellent performance in immunogenicity and safety. However, its adverse effects in immunosuppressed individuals warrant the search for a safer vector in the following clinic trails. In this study, we deleted the C7L and K1L genes of VTT and constructed six(More)
Recent technological advances in atmospheric plasmas have made the creation of non-thermal atmospheric pressure plasma (NTP) possible for utilization in the medical field. Although accumulated evidence suggests that NTP induces cell death in various cancer cell types thus offering a promising alternative treatment strategy, the mechanism underlying its(More)
UNLABELLED Receptor-interacting protein kinase 3 (RIP3) and its substrate mixed-lineage kinase domain-like protein (MLKL) are core regulators of programmed necrosis. The elimination of pathogen-infected cells by programmed necrosis acts as an important host defense mechanism. Here, we report that human herpes simplex virus 1 (HSV-1) and HSV-2 had opposite(More)
Ultratrace detection attracts great interest because it is still a challenge to the early diagnosis and drug testing. Enriching the targets from highly diluted solutions to the sensitive area is a promising method. Inspired by the fog-collecting structure on Stenocara beetle's back, a photonic-crystal (PC) microchip with hydrophilic-hydrophobic micropattern(More)
The mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) has been shown to trigger naïve immune responses through the activation of monocytes, macrophages, natural killer cells (NK cells) and antigen presenting cells (APCs). Based on the hypothesis that PA-MSHA activates natural immunity through the Toll-like receptor (TLR)(More)
Radiation-induced bystander effect (RIBE) is a biological process that has received attention over the past two decades. RIBE refers to a plethora of biological effects in non-irradiated cells, including induction of genetic damages, gene expression, cell transformation, proliferation and cell death, which are initiated by receiving bystander signals(More)
A hydrophilic-hydrophobic patterned molecularly imprinted (MIP) photonic crystal (PC) sensor is fabricated for highly sensitive tetracycline detection. The relationship between the tetracycline concentration, its corresponding color of the sensor, and the diameter of MIP-PC dot is found using a fan-shaped color card. This work provides a new strategy to(More)
In this paper, we propose an approach of multi-layered feature combination associated with support vector machine (SVM) for Chinese accent identification. The multi-layered features include both segmental and suprasegmental information, such as MFCC and pitch contour, to capture the diversity of variations in Chinese accented speech. The pitch contour is(More)
Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. Despite the completion of numerous experimental studies on RAR, the underlying mechanism has remained unclear. In this(More)
In this paper, we propose an approach for Chinese accent identification using both cepstral and prosodic features with gender-dependent model. We exploit a combination of conventional Shifted Delta Cepstrum (SDC) features and pitch contour features as an example of segmental and suprasegmental features, to capture the characteristics in Chinese accents. We(More)