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The vaccinia virus TianTan (VTT) has been modified as an HIV vaccine vector in China and has shown excellent performance in immunogenicity and safety. However, its adverse effects in immunosuppressed individuals warrant the search for a safer vector in the following clinic trails. In this study, we deleted the C7L and K1L genes of VTT and constructed six(More)
UNLABELLED Receptor-interacting protein kinase 3 (RIP3) and its substrate mixed-lineage kinase domain-like protein (MLKL) are core regulators of programmed necrosis. The elimination of pathogen-infected cells by programmed necrosis acts as an important host defense mechanism. Here, we report that human herpes simplex virus 1 (HSV-1) and HSV-2 had opposite(More)
Recent technological advances in atmospheric plasmas have made the creation of non-thermal atmospheric pressure plasma (NTP) possible for utilization in the medical field. Although accumulated evidence suggests that NTP induces cell death in various cancer cell types thus offering a promising alternative treatment strategy, the mechanism underlying its(More)
Radiation-induced bystander effect (RIBE) is a biological process that has received attention over the past two decades. RIBE refers to a plethora of biological effects in non-irradiated cells, including induction of genetic damages, gene expression, cell transformation, proliferation and cell death, which are initiated by receiving bystander signals(More)
Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. Despite the completion of numerous experimental studies on RAR, the underlying mechanism has remained unclear. In this(More)
In this paper, we propose an approach of multi-layered feature combination associated with support vector machine (SVM) for Chinese accent identification. The multi-layered features include both segmental and suprasegmental information, such as MFCC and pitch contour, to capture the diversity of variations in Chinese accented speech. The pitch contour is(More)
The mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) has been shown to trigger naïve immune responses through the activation of monocytes, macrophages, natural killer cells (NK cells) and antigen presenting cells (APCs). Based on the hypothesis that PA-MSHA activates natural immunity through the Toll-like receptor (TLR)(More)
In this paper, we propose an approach for Chinese accent identification using both cepstral and prosodic features with gender-dependent model. We exploit a combination of conventional Shifted Delta Cepstrum (SDC) features and pitch contour features as an example of segmental and suprasegmental features, to capture the characteristics in Chinese accents. We(More)
To achieve a good balance between matching accuracy and computation efficiency is a key challenge for Query-by-Humming (QBH) system. In this paper, we propose an approach of n-gram based fast match. Our n-gram method uses a robust statistical note transcription as well as error compensation method based on the analysis of frequent transcription errors. The(More)
Cholera toxin B subunit (CTB) was investigated as a classical mucosal adjuvant that can increase vaccine immunogenicity. In this study, we found out the in vitro efficacy of cholera toxin B subunit (CTB) in activating mice bone marrow-derived dendritic cells (BMDCs) through Toll-like receptor signaling pathways. In vitro RNA and transcriptional level(More)