Judy Park DeWitt

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Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology are unclear. Here, we found that optineurin actively suppressed receptor-interacting kinase 1 (RIPK1)-dependent(More)
Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein (MLKL). Recently, necroptosis-based cancer therapy has been proposed to be a novel strategy for antitumor treatment. However, a big controversy exists on whether this type of(More)
Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergizes with IFN-γ to make macrophages highly(More)
Calcineurin (Cn) is the only known Ca 2+ /calmodulin-dependent serine/threonine protein phosphatase; it is a heterodi-mer composed of a 61-kDa catalytic subunit (CnA) and a 19-kDa regulatory subunit (CnB) [1]. This enzyme, expressed in various cell types, plays an important role in modulation of T-cell activation [2], neural functions [3], apoptosis [4],(More)
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