Judy P. Golden

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Departments of 1Neurology, 2Molecular Biology and Pharmacology, and 3Pathology and Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, 4The Vollum Institute for Advanced Medical Research, Oregon Health Sciences University, Portland, Oregon 97201, 5Geneva University Medical School, CH-1211 Geneva 4, Switzerland, and 6Astra(More)
The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. It is implicated in a number of human diseases and developmental abnormalities. Here, we describe our analyses of mice expressing a Ret mutant (RetDN) with diminished(More)
The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, we show that Sirt2 expression in SCs is(More)
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