Judy Latcham

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We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS)(More)
Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is often lacking. There is a growing body of evidence showing that improving experimental design is key to improving the predictive nature of rodent studies and reducing the number of animals used in(More)
a neuronal regulator of phosphoinositide signalling Elena Di Daniel1, Emma Mead2, M. H. Selina Mok3, Erika Zambello4, Laura L. Caberlotto4, Theresa J. Pell1, Tim D. Werry1, Christopher J. Langmead3, Ajit J. Shah6, Christopher J. Ring2, Colin P. Glover1, Graham Duddy2, Judy Latcham5, Alastair Reith1, Ceri Davies1, James N. Kew3, Peter R. Maycox2 Synaptic(More)
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